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Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis
http://hdl.handle.net/2237/00030207
http://hdl.handle.net/2237/000302072f387939-c3c3-4f23-81d8-81789d8ccaa5
名前 / ファイル | ライセンス | アクション |
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Investigation_on_the_benefits (414.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-05-13 | |||||
タイトル | ||||||
タイトル | Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis | |||||
言語 | en | |||||
著者 |
Katsuno, Takayuki
× Katsuno, Takayuki× Ozaki, Takenori× Ozeki, Takaya× Hachiya, Asaka× Kim, Hangsoo× Kato, Noritoshi× Ishimoto, Takuji× Kato, Sawako× Kosugi, Tomoki× Tsuboi, Naotake× Mizuno, Masashi× Ito, Yasuhiko× Maruyama, Shoichi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | “This is a post-peer-review, pre-copyedit version of an article published in [Clinical and Experimental Nephrology]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10157-018-1590-2”. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Systemic lupus erythematosus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lupus nephritis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mycophenolate mofetil | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Therapeutic drug monitoring | |||||
抄録 | ||||||
内容記述 | Background: Mycophenolate mofetil (MMF) is recommended as a first-line immunosuppressant to treat lupus nephritis (LN). Prognosis and therapeutic response in LN are known to vary depending on race. We investigated the benefits of MMF and therapeutic drug monitoring (TDM) in the treatment of Japanese LN patients. Methods: In this retrospective cohort study, a total of 20 patients with LN who started MMF treatment were included. Clinical data were collected regularly after MMF administration. We evaluated complete remission (CR) rate as the primary outcome. Predictors of CR were identified using univariate and multivariate analyses. In the research of TDM, the correlation with the area under the curve (AUC) was analyzed at MMF dose, single-point value, treatment response, and adverse events. Results: Overall, 70% of cases showed CR; both flare-ups and refractory cases had favorable results. Cases of LN with nephrotic syndrome (NS) or class III/IV + V showed a significantly lower CR rate (p < 0.005). The ratio of maintaining CR after MMF therapy was as high as 85.7%. In multivariate analysis, NS was an independent negative predictor of CR (HR 0.09, 95% confidence interval 0.01–0.81; p = 0.03). The relationship between AUC and MMF dose was low, and AUC correlated with trough level (r = 0.73). AUC tended to be high in the treatment responder (p = 0.09), but did not correlate with adverse events of infection (p = 0.92). Conclusion: MMF is a beneficial treatment option for Japanese LN patients, and further investigation on TDM-based therapy is needed. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2019/12/01 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Springer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s10157-018-1590-2 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1342-1751 | |||||
書誌情報 |
en : Clinical and Experimental Nephrology 巻 22, 号 6, p. 1341-1350, 発行日 2018-12 |
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著者版フラグ | ||||||
値 | author |