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An autopsy case of cortical superficial siderosis with persistent abnormal behavior
http://hdl.handle.net/2237/25744
http://hdl.handle.net/2237/257449cccba59-5e2e-4647-945d-5eed3508052a
名前 / ファイル | ライセンス | アクション |
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s1-ln22637059.pdf ファイル公開:2017/12/01 (2.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-03-22 | |||||
タイトル | ||||||
タイトル | An autopsy case of cortical superficial siderosis with persistent abnormal behavior | |||||
言語 | en | |||||
著者 |
Torii, Youta
× Torii, Youta× Iritani, Shuji× Fujishiro, Hiroshige× Sekiguchi, Hirotaka× Habuchi, Chikako× Umeda, Kentaro× Matsunaga, Shinji× Mimuro, Maya× Ozaki, Norio× Yoshida, Mari× Fujita, Kiyoshi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is the peer reviewed version of the following article: [Torii, Y., Iritani, S., Fujishiro, H., Sekiguchi, H., Habuchi, C., Umeda, K., Matsunaga, S., Mimuro, M., Ozaki, N., Yoshida, M., and Fujita, K. (2016) An autopsy case of cortical superficial siderosis with persistent abnormal behavior. Neuropathology, 36: 544–550. doi: 10.1111/neup.12301.<br/>], which has been published in final form at [http://doi.org/10.1111/neup.12301]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
抄録 | ||||||
内容記述 | In recent years, MRI has revealed cortical superficial siderosis (cSS), which exhibits hemosiderin deposition in only the cortical surface. However, the associations between the histological findings and clinical symptoms of cSS remain unclear. We herein report an autopsy case of a 75-year-old Japanese man with cSS with persistent abnormal behavior according to cognitive impairment, hallucination and delusion. At 73 years of age, the patient presented with unusual behavior that indicated auditory hallucination and delusion. One year later, he was admitted to the hospital for malignant lymphoma. On admission, cognitive impairment was detected by a screening test. Soon after hospitalization, he presented with active delirium including visual hallucination and delusion. The patient's excited behavior was improved by the administration of a major tranquilizer. However, the abnormal behavior and cognitive impairment persisted. At 75 years of age, he died of heart failure. A neuropathological investigation revealed hemosiderin depositions in the superficial layer of the cortex in the medial and lateral frontal lobe, the lateral temporal lobe, the parietal lobe, and the medial and lateral occipital lobe. Neuritic plaques and diffuse plaques were extensively observed, which corresponded to Braak stage C and CERAD B, although NFTs were observed that corresponded to Braak stage II. Cortical amyloid angiopathy was not observed in any regions. Ischemic change of brain was also mild. Our report suggests that localized deposition of hemosiderin in the cortex might affect the manifestation of cognitive impairments and hallucination. Further clinicopathological studies are needed to clarify the clinical manifestations of patients with cSS. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Wiley | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1111/neup.12301 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0919-6544 | |||||
書誌情報 |
en : Neuropathology 巻 36, 号 6, p. 544-550, 発行日 2016-12 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://doi.org/10.1111/neup.12301 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/25744 | |||||
識別子タイプ | HDL |