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Comparison of high-dose and low-dose corticosteroid therapy for refractory Mycoplasma pneumoniae pneumonia in children
http://hdl.handle.net/2237/00030546
http://hdl.handle.net/2237/000305461ea757ab-b1fa-4420-8157-306d77109f7c
名前 / ファイル | ライセンス | アクション |
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MS_Okumura_repository (452.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-07-11 | |||||
タイトル | ||||||
タイトル | Comparison of high-dose and low-dose corticosteroid therapy for refractory Mycoplasma pneumoniae pneumonia in children | |||||
言語 | en | |||||
著者 |
Okumura, Toshihiko
× Okumura, Toshihiko× Kawada, Jun-ichi× Tanaka, Masaharu× Narita, Kotaro× Ishiguro, Tomonori× Hirayama, Yuji× Narahara, Sho× Tsuji, Genki× Sugiyama, Yuichiro× Suzuki, Michio× Tsuji, Takeshi× Hoshino, Shin× Nakatochi, Masahiro× Muramatsu, Hideki× Kidokoro, Hiroyuki× Takahashi, Yoshiyuki× Sato, Yoshiaki× Miyajima, Yuji× Uno, Nozomi× Nagai, Noriko× Ando, Shotaro× Sudo, Yuji× Naruse, Kazuhisa× Takahashi, Yuma× Suzui, Ryosuke× Nagata, Yoshihiro× Kawabe, Takashi× Shibata, Motohiro× Shibata, Yusuke× Morishita, Masashi× Kajita, Mitsuharu× Ito, Takuto× Kido, Shinji× Hasegawa, Shinji× Ikeda, Kei× Tokumo, Noriko× Kato, Maki× Kato, Koji× Fukumi, Daichi× Doi, Satoru× Omori, Marei× Watanabe, Nobuhiro× Takada, Hiroyuki |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mycoplasma pneumoniae pneumonia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Refractory pneumonia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Corticosteroids | |||||
抄録 | ||||||
内容記述 | Background: Mycoplasma pneumoniae pneumonia (MPP) is generally a self-limiting disease, but it may become refractory. It is thought that refractory MPP is linked to the excessive immunologic responses of the host. Consequently, the use of adjunctive systemic corticosteroids may have beneficial effects. In this study, we compared the effects of high- and low-dose corticosteroid therapy in a pediatric population with refractory MPP. Methods: We retrospectively collected data from 91 pediatric MPP patients treated with adjunctive systemic corticosteroids between April 2014 and October 2016. The patients were divided into the following two groups: high-dose corticosteroid group (2 mg/kg/day or more of prednisolone equivalents; n = 38) and low-dose corticosteroid group (<2 mg/kg/day; n = 53). Additionally, we compared the number of febrile days post-corticosteroid administration. We used 25 paired patients in a propensity score matching analysis to correct for confounding factors both by age and by days (from onset till corticosteroid therapy initiation). Results: We observed that in the high-dose corticosteroid group defervescence following corticosteroid therapy initiation was achieved significantly earlier and length of hospitalization was significantly shorter (0.8 ± 1.0 vs. 1.5 ± 1.4 days and 8.2 ± 2.4 vs. 10.7 ± 2.7 days, respectively). In the propensity score matching, we observed that significant differences in the length of fever following corticosteroid therapy initiation and hospitalization were still present. Further, neither of the groups developed corticosteroid-related adverse events. Conclusion: Our results suggest that patients with refractory MPP treated with high-dose corticosteroid could achieve defervescence earlier and have a shorter hospitalization. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2020-05-01 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Elsevier | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.jiac.2019.01.003 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1341-321X | |||||
書誌情報 |
en : Journal of Infection and Chemotherapy 巻 25, 号 5, p. 346-350, 発行日 2019-05 |
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著者版フラグ | ||||||
値 | author |