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Cluster of differentiation 36 gene polymorphism (rs1761667) is associated with dietary MUFA intake and hypertension in a Japanese population
http://hdl.handle.net/2237/00030896
http://hdl.handle.net/2237/0003089644c38a8c-bf71-41d6-b5a6-2b88087d7904
名前 / ファイル | ライセンス | アクション |
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cluster_of_differentiation_36_gene_polymorphism_rs1761667 (429.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-11-15 | |||||
タイトル | ||||||
タイトル | Cluster of differentiation 36 gene polymorphism (rs1761667) is associated with dietary MUFA intake and hypertension in a Japanese population | |||||
言語 | en | |||||
著者 |
Fujii, Ryosuke
× Fujii, Ryosuke× Hishida, Asahi× Suzuki, Koji× Imaeda, Nahomi× Goto, Chiho× Hamajima, Nobuyuki× Wakai, Kenji× Kondo, Takaaki |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This article has been published in a revised form in [British Journal of Nutrition] [https://doi.org/10.1017/S0007114519000679]. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © 2019 Cambridge University Press. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD36 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Blood pressure | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fatty acids | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Single nucleotide polymorphisms | |||||
抄録 | ||||||
内容記述 | Cluster of differentiation 36 (CD36) is a membrane receptor expressed on a wide variety of human cells. CD36 polymorphisms are reportedly associated with oral fat perception, dietary intake and metabolic disorders. The present study examined associations of two CD36 polymorphisms (rs1761667 and rs1527483) and dietary fat intake, and metabolic phenotypes in a Japanese population. This cross-sectional study was conducted based on clinical information collected from health check-ups in Japan (n 495). Dietary nutrient intake was estimated from a validated short FFQ and adjusted for total energy intake using the residual method. Mean blood pressure was calculated from systolic blood pressure (SBP) and diastolic blood pressure (DBP). Hypertension was defined as SBP ≥ 130 mmHg and/or DBP ≥ 85 mmHg, or use of antihypertensive drugs. Genotyping was performed using PCR with confronting two-pair primers method. Mean age was 63·4 (SD 9·9) years. Individuals with the AA genotype showed higher total fat and MUFA intake (standardised β = 0·110 and 0·087, P = 0·01 and 0·05, respectively) compared with the GG and GA genotypes. For metabolic phenotypes, the AA genotype of rs1761667 had a lower blood pressure compared with the GG genotype (standardised β = –0·123, P = 0·02). Our results suggested that the AA genotype of rs1761667 in the CD36 gene was associated with higher intake of total fat and MUFA and lower risk of hypertension in a Japanese population. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開日: 2020/06/14 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Cambridge University Press | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1017/S0007114519000679 | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0007-1145 | |||||
書誌情報 |
en : British Journal of Nutrition 巻 121, 号 11, p. 1215-1222, 発行日 2019-06-14 |
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著者版フラグ | ||||||
値 | author |