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Cell Biology of Caveolae and Its Implication for Clinical Medicine
https://doi.org/10.18999/nagjms.63.1-2.9
https://doi.org/10.18999/nagjms.63.1-2.9a00f6a9d-da69-46a1-a865-961046084e3d
名前 / ファイル | ライセンス | アクション |
---|---|---|
v63n12p9_18.pdf (1.3 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2012-08-30 | |||||
タイトル | ||||||
タイトル | Cell Biology of Caveolae and Its Implication for Clinical Medicine | |||||
言語 | en | |||||
著者 |
FUJIMOTO, TOYOSHI
× FUJIMOTO, TOYOSHI |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | caveolae | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | caveolin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | raft | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | signal transduction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cholesterol | |||||
抄録 | ||||||
内容記述 | Caveolae are small invaginations of the plasma membrane found in many cell types, and caveolins are integral membrane proteins that form the framework of caveolae. In the past several years, research on caveolae has developed explosively, and caveolae and/or caveolins have been shown to play many important roles in cell physiology: in particular, they are thought to be related to signal transduction, cholesterol transport, endocytosis and tumor suppression. On the other hand, some studies have suggested that another membrane domain called rafts is also involved in the same processes, and some confusion remains concerning the relationship between these two domains. Abnormalities in caveolae and/or caveolins have been found in various diseases, including cancer, atherosclerosis, muscular dystrophy and the Alzheimer's disease, which may make this domain a new focus for pharmacological research. This review will focus on the cell biology of caveolae, caveolins and rafts, and then summarize the implications of these findings for clinical studies. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.63.1-2.9 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/6312/6312.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 63, 号 1-2, p. 9-18, 発行日 2000-05 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/16761 | |||||
識別子タイプ | HDL |