2024-03-28T21:10:19Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00003941
2023-11-16T06:42:15Z
499:508:509:514
Squamous Cell Carcinoma of the Vulva and Adjacent Lesions Treated at Nagoya University Hospital from 1965 to 1997
AKASHI, KOMEI
NAGASAKA, TETSURO
NAKASHIMA, NOBUO
HARADA, TOMOKO
OKAMOTO, TOMOMITSU
MIZUTANI, SHIGEHIKO
ISHIKO, HIROAKI
open access
Squamous cell carcinoma of the vulva
lichen sclerosus
vulvar intraepithelial neoplasia-HPV
Japan has a lower incidence of vulvar squamous cell carcinoma (VSCC) than Western nations. To pinpoint the reasons for this, we reviewed biopsy samples from all cases treated at Nagoya University Hospital over the past 33 years in order to investigate the background lesions for VSCC. Two of 36 VSCC patients had adjacent or coexisting lichen sclerosus (LS), 5 had squamous cell hyperplasia (SCH), and 16 had vulvar intraepithelial neoplasia (VIN). There were 8 cases in which these lesions were thought to be the origin of the VSCC, 1 in which keratinizing squamous cell carcinoma (KSC) was seen in LS, 1 in which verrucous SCH was the origin, and 6 in which 4 basaloid carcinoma and 2 warty carcinoma developed from basaloid VIN and warty VIN, respectively. Although 8 other cases of keratinizing or non-keratinizing squamous cell carcinomas (NSC) coexisted with VIN NOS (not otherwise specified), differentiated VIN or basaloid VIN, we could not be histologically certain of the origin. Among 22 VSCC patients tested for HPV DNA, only an 84-year-old woman presenting a histological feature of KSC tested positive by in situ hybridization (ISH). It was considered that LS and SCH had little and VIN considerable capacity to cause the malignancy of VSCC. We surmise that in Japan the majority of squamous cell carcinoma is unrelated to HPV. One reason for the low incidence of VSCC is largely due to race; the homogeneous, monoethnic Japanese population, as well as the few cases of HPV-related VSCC.
Nagoya University School of Medicine
2001-11
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.64.3-4.109
http://hdl.handle.net/2237/5373
https://nagoya.repo.nii.ac.jp/records/3941
10.18999/nagjms.64.3-4.109
2186-3326
0027-7622
Nagoya Journal of Medical Science
64
3-4
109
121
https://nagoya.repo.nii.ac.jp/record/3941/files/nj6434.pdf
application/pdf
144.3 kB
2018-02-19