2024-03-29T09:09:46Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00005949
2023-01-26T06:18:52Z
329:333:334:737
Effect of ACTH on the Proliferation of the Rat Adrenal Gland
Kobayashi, Hironobu
Imai, Tsuneo
Kambe, Fukushi
Mirza, Rusella
Seo, Hisao
open access
ACTH
PCNA
adrenal gland
proliferation
Although the regulation of steroidogenesis in adrenal fasciculate and reticularis is stimulated by adrenocorticotrophic hormone (ACTH), its role on the proliferation of adrenocortical call is not established. We thus investigated the effect of ACTH on the proliferation of adrenocortical cells by analyzing the expression of proliferating cell nuclear antigen (PCNA). Endogeneous secretion of ACTH was inhibited by treatment with dexamethasone for 5 days. At intervals after ACTH treatment, homogenate of the adrenal gland was subjected to Western blot analysis. PCNA expression was detected in control rat without any treatment. Dexamethasone administration for 5 days resulted in the reduction of PCNA expression. ACTH administration to the dexamethasone treated rats increased PCNA expression at 24 hr. It is thus demonstrated that ACTH increases cellular proliferation in adrenal cortex.
国立情報学研究所で電子化したコンテンツを使用している。
Reaserch Institue of Environmental Medicine, Nagoya University
2003-12
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/envm.47.20
http://hdl.handle.net/2237/7562
https://nagoya.repo.nii.ac.jp/records/5949
10.18999/envm.47.20
0287-0517
Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University
47
20
21
https://nagoya.repo.nii.ac.jp/record/5949/files/20-21.pdf
application/pdf
230.1 kB
2018-02-19