2024-03-29T15:18:23Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00005988
2023-01-26T06:22:42Z
329:333:334:737
Effectiveness of Centrifuge-induced Artificial Gravity with Ergometric Exercise as a Countermeasure during Simulated Microgravity Exposure in Humans
Iwase, Satoshi
Fu, Qi
Morimoto, Eiichi
Takada, Hiroki
Kamiya, Atsunori
Michikami, Daisaku
Kawanokuchi, Jun
Shiozawa, Tomoki
Hirayanagi, Kaname
Iwasaki, Ken-ichi
Yajima, Kazuyoshi
Mano, Tadaaki
open access
Artificial gravity
ergometric exercise
deconditioning
microneurography
sympathetic nerve activity
To test the effectiveness of centrifuge-induced artificial gravity with ergometric exercise, 12 healthy young men (20.7±1.9yrs) were exposed to simulated microgravity for 14 days of-6°head-down bedrest. Half the subjects were randomly selected and loaded 1.2 G artificial gravity with 60 W (four out of six subjects) or 40 W (two out of six subjects) of ergometric workload on days 1,2,3,5,7,9,11.12,13,14(CM group). The rest of the subjects served as the control. Anti-G score, defined as the G-load x running time to the endpoint, was significantly elongated by the load of the centrifuge-ergometer.Plasma volume loss was suppressed(-5.0±2.4 vs-16.4±1.9%),and fluid volume shift was prevented by the countermeasure load. Elevated heart rate and muscle sympathetic nerve activity after bedrest were counteracted, and exaggerated response to head-up tilt was also suppressed. Centrifuge-induced artificial gravity with exercise is effective in preventing cardiovascular deconditioning due to microgravity exposure, however, as effective and appropriate regimen (magnitude of G-load and exercise workload)should be determined in future studies.
国立情報学研究所で電子化したコンテンツを使用している。
Research Institute of Environmental Medicine, Nagoya University
2003-12
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/envm.47.76
http://hdl.handle.net/2237/7604
https://nagoya.repo.nii.ac.jp/records/5988
10.18999/envm.47.76
0287-0517
Environmental Medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University
47
76
80
https://nagoya.repo.nii.ac.jp/record/5988/files/76-80.pdf
application/pdf
502.7 kB
2018-02-19