2024-03-29T15:21:14Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00007923
2023-11-16T06:34:13Z
499:508:509:955
METABOLIC SYNDROME DEFINED BY NEW CRITERIA IN JAPANESE IS ASSOCIATED WITH INCREASED LIVER ENZYMES AND C-REACTIVE PROTEIN
Taki, Kentaro
Nishio, Kazuko
Hamajima, Nobuyuki
Niwa, Toshimitsu
open access
Metabolic syndrome
Japanese
Liver enzymes
Inflammation
Metabolic syndrome (MetS) is characterized by the presence of atherogenic risk factors, and is associated with a marked increase in the risk of cardiovascular disease. Recently, the criteria of MetS were newly defined in Japan.We examined the relationship between MetS and the various metabolic parameters in Japanese subjects. This study included 458 Japanese subjects undergoing medical checkups at Nagoya University Hospital. New criteria developed by the joint committee of eight Japanese medical societies for the clinical recognition of MetS were adopted. We examined the association between MetS and various metabolic parameters, including liver enzymes (alanine aminotransferase, ALT; gamma glutamyltransferase, GGT) and highly sensitive C-reactive protein (hsCRP). The mean overall prevalence of MetS was 8.7%(male: 12.9%; female: 2.2%, p=0.0001). MetS was significantly associated with elevated ALT (>45 IU/L) (OR: 3.37, 95% CI: 1.19–9.52, p<0.05) and GGT (>64 IU/L in males, >45 IU/L in females) (OR: 4.96, 95% CI: 2.31–10.66, p=0.0001), respectively. MetS was also significantly associated with elevated hsCRP (≥ 0.1 ng/mL) (OR: 2.77, 95% CI: 1.20–6.41, p<0.05). Thus, MetS was associated with elevated liver enzymes (especially, GGT), and inflammation (hsCRP).
Nagoya University School of Medicine
2008-03
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.70.1-2.1
http://hdl.handle.net/2237/9646
https://nagoya.repo.nii.ac.jp/records/7923
10.18999/nagjms.70.1-2.1
2186-3326
0027-7622
Nagoya Journal of Medical Science
70
1-2
1
9
https://nagoya.repo.nii.ac.jp/record/7923/files/p01-09_Taki.pdf
application/pdf
282.7 kB
2018-02-19