2024-03-28T22:34:50Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00013451
2023-11-16T06:36:40Z
499:508:509:1359
CD40/CD40 LIGAND INTERACTIONS IN IMMUNE RESPONSES AND PULMONARY IMMUNITY
KAWABE, TSUTOMU
MATSUSHIMA, MIYOKO
HASHIMOTO, NAOZUMI
IMAIZUMI, KAZUYOSHI
HASEGAWA, YOSHINORI
open access
CD40
Immunity
B cells
Alveolar macrophages
The CD40 ligand/CD40 pathway is widely recognized for its prominent role in immune regulation and homeostasis. CD40, a member of the tumor necrosis factor receptor family, is expressed by antigenpresenting cells, as well as non-immune cells and tumors. The engagement of the CD40 and CD40 ligands, which are transiently expressed on T cells and other non-immune cells under inflammatory conditions, regulates a wide spectrum of molecular and cellular processes, including the initiation and progression of cellular and humoral adaptive immunity. Based on recent research findings, the engagement of the CD40 with a deregulated amount of CD40 ligand has been implicated in a number of inflammatory diseases. We will discuss the involvement of the CD40 ligand/CD40 interaction in the pathophysiology of inflammatory diseases, including autoimmune diseases, atherothrombosis, cancer, and respiratory diseases.
Nagoya University School of Medicine
2011-08
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.73.3-4.69
http://hdl.handle.net/2237/15350
https://nagoya.repo.nii.ac.jp/records/13451
10.18999/nagjms.73.3-4.69
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7334/7334.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
73
3-4
69
78
https://nagoya.repo.nii.ac.jp/record/13451/files/v73n34p69_78.pdf
application/pdf
457.1 kB
2018-02-20