2024-03-28T14:41:37Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00014185
2023-11-16T06:24:38Z
499:508:509:616
A CASE OF PRIMARY GLUCOCORTICOID RESISTANCE
KAWAKUBO, AKITOSHI
SUZUKI, ATSUSHI
YOKOI, HISASHI
KAKIYA, SATOSHI
MORIKAWA, MITSUYA
OISO, YUTAKA
YAMAMOTO, MASAHIRO
open access
Dexamethasone
Glucocorticoid resistance
Hypokalemia
A 79-year-old woman developed hypokalemia and metabolic alkalosis after breast cancer surgery. She was suspected of having primary glucocorticoid resistance on the basis of high plasma ACTH and serum cortisol levels without the features of Cushing's syndrome. To clarify the end-organ resistance to cortisol, we characterized the glucocorticoid receptors (GR) in cultured skin fibroblasts from the patient. The GRs in whole cell assays decreased binding affinity (Kd = 11.1 +/- 0.6 nM) and the number of binding sites for [3H]dexamethasone (binding capacity was 15,600 +/- 1,255 sites per cell). These results strongly suggest that our patient had primary glucocorticoid resistance caused both by a decreased number of GRs and a reduction in the affinity of GRs to cortisol.
Nagoya University School of Medicine
1995-12-25
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.58.3-4.143
http://hdl.handle.net/2237/16090
https://nagoya.repo.nii.ac.jp/records/14185
10.18999/nagjms.58.3-4.143
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5834/5834.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
58
3-4
143
147
https://nagoya.repo.nii.ac.jp/record/14185/files/v58n34p143_147.pdf
application/pdf
328.3 kB
2018-02-20