2024-03-29T15:35:17Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00014788
2023-01-16T04:02:12Z
499:960:1165
Differing effects of vasopressin on regional cerebral blood flow of dogs following intracisternal vs. intra-arterial administration
Tsugane, Shinichiro
Suzuki, Yoshio
Kano, Takahisa
Takayasu, Masakazu
Shibuya, Masato
Sugita, Kenichiro
open access
This is the author's version of a work that was accepted for publication in Life Sciences. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Life Sciences. v.54, n.15, 1994, p.PL241–PL246 http://dx.doi.org/10.1016/0024-3205(94)00424-2
We investigated the differential effect of the intracisternal and intraarterial administration of vasopressin on the regional cerebral blood flow (rCBF) in the parietal cortex of dogs. Regional CBF, velocity and blood volume were assayed by laser flowmetry. The intracisternal injection of 1 nmol vasopressin significantly increased the rCBF and velocity, without affecting blood volume. However, the intravertebral arterial injection of 1 nmol vasopressin significantly decreased the rCBF and velocity. This discrepancy can be explained by a difference in the affected vasculature; large blood vessels in the subarachnoid space vs. whole cerebral vascular system. The intracisternal and intraarterial injection of the nitric oxide inhibitor NG-monomethyl-L-arginine reduced the rCBF from the base line, and significantly suppressed the rCBF elevation induced by vasopressin. The effect of vasopressin may be considered as the summation of the increased flow from the dilated large vessels via the release of nitric oxide from the endothelium, and of the decreased flow from the contracted small vessels.
名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成6年3月25日 津金慎一郎氏の博士論文として提出された
Elsevier
1994
eng
doctoral thesis
http://hdl.handle.net/2237/16721
https://nagoya.repo.nii.ac.jp/records/14788
https://doi.org/10.1016/0024-3205(94)00424-2
0024-3205
Life Sciences
54
15
PL241
PL246
甲第3020号
博士(医学)
1994-01-01
13901
名古屋大学
NAGOYA University
https://nagoya.repo.nii.ac.jp/record/14788/files/k3020.pdf
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709.2 kB
2018-02-20