2024-03-29T08:17:56Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00015090
2023-01-16T04:02:30Z
499:960:1165
Effect of Topical Application of Nitroglycerin on Cochlear Blood Flow
ニトログリセリン局所投与における蝸牛血流への影響
ITO, ASAKO
NAKASHIMA, TSUTOMU
YANAGITA, NORIYUKI
伊藤, 麻子
中島, 務
柳田, 則之
open access
NOTICE: This is the author's version of a work that was accepted for publication in American Journal of Otolaryngology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in American Journal of Otolaryngology. v.16, n.3, 1995, p.177-180, DOI: http://dx.doi.org/10.1016/0196-0709(95)90098-5
Purpose: To investigate whether topical application of the vasodilator nitroglycerin would increase cochlear blood flow without adversely affecting inner ear function. Materials and Methods: The effect of topical application of nitroglycerin to the round window membrane on cochlear blood flow was measured in 33 guinea pigs with a laser Doppler flowmeter. Endocochlear potential, as an indicator of inner ear function, was recorded by a glass micro-electrode inserted through the round window membrane in a second series of 27 guinea pigs. Blood pressure was also monitored in both experiments. Results: Low doses (0.0001 to 1 wg) of nitroglycerin induced an increase in cochlear blood flow with no change in blood pressure. The cochlear blood flow was maximally increased by approximately 50%. A high dose (50 ILg) of nitroglycerin induced a significant decrease in blood pressure but did not significantly affect endocochlear potential. Conclusions: Topical application of nitroglycerin may be useful in increasing cochlear blood flow in various inner ear diseases.
名古屋大学博士学位論文 学位の種類 : 博士(医学)(論文) 学位授与年月日:平成7年3月31日 伊藤麻子氏の博士論文として提出された
Elsevier
1995-05
eng
doctoral thesis
http://hdl.handle.net/2237/17092
https://nagoya.repo.nii.ac.jp/records/15090
https://doi.org/10.1016/0196-0709(95)90098-5
0196-0709
American Journal of Otolaryngology
16
3
177
180
乙第4770号
博士(医学)
1995-05-01
13901
名古屋大学
Nagoya University
https://nagoya.repo.nii.ac.jp/record/15090/files/o4770.pdf
application/pdf
1.7 MB
2018-02-20