2024-03-28T15:44:36Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00015268
2023-11-16T06:02:06Z
499:508:509:1434
Production of Metastases by Treatment with Carcinostatic Agents : III. Low Concentration of Carcinostatic Agents on the Cells
KONDO, TATSUHEI
ICHIHASHI, HIDEHITO
SHIZU, YUICHI
MOMOI, YOSHIMASA
KAWASHIMA, YASURO
YAMADA, HISAYOSHI
ISHII, MASATAKA
open access
The effects of treatment with various doses of carcinostatic agents on tumor growth have been studied. In animal experiments. treatment with low concentrations of nitrogen mustard N-oxide resulted in an early death of mice bearing Ehrlich ascites carcinoma and an increase in the number of circulating Yoshida sarcoma cells. The growth of subcutaneously implanted Yoshida sarcoma was stimulated after contact of the cells with low concentrations of nitrogen mustard N-oxide in vitro or intraperitoneally. Low concentrations of Mitomycin-C and Chromomycin A3 also showed increase of tumor growth and metastasis formation. In vitro study showed that the proliferation of HeLa cells was stimulated by adding low concentrations of nitrogen mustard N-oxide. Mitomycin-C, and Chromomycin A3 into the culture media. In clinical studies, much more cancer cells were released into the stomach cavity after the administration of nitrogen mustard N-oxide, Mitomycin-C, and Chromomycin A3.
Nagoya University School of Medicine
1973-11
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.36.1.1
http://hdl.handle.net/2237/17285
https://nagoya.repo.nii.ac.jp/records/15268
10.18999/nagjms.36.1.1
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/361/361.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
36
1
1
10
https://nagoya.repo.nii.ac.jp/record/15268/files/v36n1p1_10.pdf
application/pdf
1.2 MB
2018-02-20