2024-03-29T09:34:40Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00015281
2023-11-16T06:02:35Z
499:508:509:1437
Histochemical Study on the Activity of the Enzymes in Human Hepatomas
KOBAYASHI, HISANDO
TAUCHI, HISASHI
open access
Ten cases of human hepatoma obtained at surgery and autopsy were studied enzyme-histochemically, and compared with gastric carcinoma, intrahepatic bile duct carcinoma and prostate carcinoma. The enzymes studied were glucose-6-phosphatase, acid phosphatase, alkaline phosphatase, succinic dehydrogenase, cytochrome oxidase, and peroxidase. In conventional stained sections, case 1 was grade I and II hepatocellular carcinoma by the classification of Edmondson. Case 2 and case 3 were grade IV or more malignant than grade III, and the remaining were almost all grade III. Case 1, in which all enzymes except alkaline phosphatase were histochemically demonstrated in hepatoma cells, could belong to such minimum deviation hepatoma. Acid phosphatase was demonstrated as more prominent granules in the hepatocellular carcinoma cells of all cases. Succinic dehydrogenase was noticed to be very weak or negative except for case 1, but cytochrome oxidase was positive in all cases. Glucose-6-phosphatase was histochemically demonstrated in all cases examined, but the activity was low except for case 1, and negative in control cancer cases. Peroxidase was generally low in activity in all hepatomas except for case 1. The intensity of glucose-6-phosphatase and peroxidase activities in the present human hepatomas may be related to a more detailed and accurate differentiation of hepatocellular carcinoma than the classification of Edmondson by conventional stained sections.
Nagoya University School of Medicine
1975-03
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.37.3-4.45
http://hdl.handle.net/2237/17298
https://nagoya.repo.nii.ac.jp/records/15281
10.18999/nagjms.37.3-4.45
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/3734/3734.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
37
3-4
45
57
https://nagoya.repo.nii.ac.jp/record/15281/files/v37n34p45_57.pdf
application/pdf
1.5 MB
2018-02-20