2024-03-28T12:11:36Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00015345
2023-11-16T06:04:09Z
499:508:509:1446
The Effect of Large Dose Intratumoral Administration of OK-432 in Advanced Cancer Patients
SAKAMOTO, JUNICHI
KONDO, TATSUHEI
KAMEl, HIDEO
ICHlHASHl, HIDEHITO
YAMAMURA, YOSHITAKA
open access
To clarify the effect of large dose intratumoral administration of OK-432, experimental and clinical investigations were perfomed. In the experimental study, 250 KE/Kg OK-432 was administered into S-180 sarcoma in ddN mice. Mice treated by OK-432 showed significant increase in delayed hypersensitivity reaction and elongation in the survival times. In the clinical study, 50 KE OK-432 was injected intratumorally during the surgery for the advanced and inoperable malignancy. PHA and PPD skin test reactions, IgG titers, and lymphocyte counts were elevated in the group received the large dose of OK-432. The treatment seemed to contribute to the prolongation of survival times during 3 months after the operation.
Nagoya University School of Medicine
1979-12
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.42.1-2.27
http://hdl.handle.net/2237/17363
https://nagoya.repo.nii.ac.jp/records/15345
10.18999/nagjms.42.1-2.27
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4212/4212.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
42
1-2
27
36
https://nagoya.repo.nii.ac.jp/record/15345/files/v42n12p27_36.pdf
application/pdf
553.4 kB
2018-02-20