2024-03-29T07:15:20Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00015493
2023-11-16T05:50:47Z
499:508:509:1463
Invasive Character of Malignant Endothelial Cells in Vinyl-Chloride-Induced Liver Angiosarcoma
HAYASHI, HISAO
SAKAMOTO, NOBUO
AOI, TSUNETO
FUKUMURA, AKIRA
MANO, HIROSHI
INAGAKI, TAKAO
open access
Vinyl chloride
Angiosarcoma
Cavernous tissue
Liver tumor
Endothelial cells
Two cases of vinyl-chloride-induced angiosarcoma of the liver were investigated with special reference to the invasive character of malignant endothelial cells. Histological findings of the liver were similar in both cases. The liver angiosarcoma was multicentric and consisted of three portions: a peripheral parenchymal area, an intermcdiate mottled area, and a central cavernous area. Microscopically the intermediate area showed a mixture of fibrosis and cell infiltration of various patterns. At the periphery, yellowish brown parenchymal tissues remained and were always associated with sinusoidal changes, from non-cellular dilatation to trabecular growth of the small round cells. Under electron microscope, the small round cells showed direct contact with red blood cells and hepatocytes. Thus, the sinusoidal small cell infiltration is thougth to be an initial lesion of angiosarcomatous transformation. Because none of the liver is free from these sinusoidal changes, partial hepatectomy would not be indicated even in a patient with few cavernous lesions.
Nagoya University School of Medicine
1990-03
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.52.1-4.13
http://hdl.handle.net/2237/17511
https://nagoya.repo.nii.ac.jp/records/15493
10.18999/nagjms.52.1-4.13
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5214/5214.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
52
1-4
13
17
https://nagoya.repo.nii.ac.jp/record/15493/files/v52n14p13_17.pdf
application/pdf
673.1 kB
2018-02-20