2024-03-29T15:46:20Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00015579
2023-11-16T05:37:44Z
499:508:509:1468
The Regulation of Sleep and Wakefulness by the Hypothalamic Neuropeptide Orexin/Hypocretin
INUTSUKA, AYUMU
YAMANAKA, AKIHIRO
open access
orexin/hypocretin
sleep
hypothalamus
optogenetics
neuropeptide
Orexins, also known as hypocretins, are neuropeptides that are exclusively expressed by neurons in the lateral hypothalamic area. Although originally recognized as regulators of feeding behavior, orexins are now mainly regarded as key modulators of the sleep/wakefulness cycle. In addition, anatomical studies of neural networks and analyses of transgenic mice have revealed integrated roles for orexin neurons in the coordination of emotion, energy homeostasis, and the reward system. A functional link between the limbic system and orexin neurons may be important for increasing vigilance in response to emotional stimuli. These findings suggest that orexin neurons relay information about an organism’s environment to maintain the proper amount of sleep and wakefulness in animals.
Nagoya University School of Medicine
2013-02
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.75.1-2.29
http://hdl.handle.net/2237/17598
https://nagoya.repo.nii.ac.jp/records/15579
10.18999/nagjms.75.1-2.29
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7512/7512.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
75
1-2
29
36
https://nagoya.repo.nii.ac.jp/record/15579/files/03_Yamanaka.pdf
application/pdf
392.9 kB
2018-02-20