2024-03-29T10:30:34Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00015586
2023-11-16T05:38:01Z
499:508:509:1468
No Association between MTHFR C677T and Serum Uric Acid Levels among Japanese with ABCG2 126QQ and SLC22A12 258WW
HINOHARA, YUKAKO
NAITO, MARIKO
OKADA, RIEKO
YIN, GUAN
HIGASHIBATA, TAKAHIRO
TAMURA, TAKASHI
KAWAI, SAYO
MORITA, EMI
WAKAI, KENJI
MATSUO, HIROTAKA
MORI, ATSUYOSHI
HAMAJIMA, NOBUYUKI
open access
Serum uric acid
Urate transporter polymorphisms
MTHFR C677T
Several genome-wide association studies (GWAS) have revealed that single nucleotide polymorphisms (SNPs) of ABCG2 and SLC22A12 were strongly associated with serum uric acid (SUA), but those of methylene tetrahydrofolate reductase (MTHFR) were not. However, there were several studies indicating the association with MTHFR C677T polymorphism. This study examined the association with the polymorphism, taking into account the genotypes of ABCG2 Q126X and SLC22A12 W258X. Subjects were 5,028 health checkup examinees of Seirei Preventive Health Care Center (3,416 males and 1,612 females) aged 35 to 69 years, who participated in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). Hyperuricemia was defined as SUA equal to 7 mg/dL or over. The genotype frequency was 35.9% for CC, 48.1% for CT, and 16.0% for TT, being in Hardy-Weinberg equilibrium (p=0.90). Among 4,425 participants with ABCG2 126QQ and SLC22A12 258WW who were not under medication for hyperuricemia, the mean SUA was 5.6 mg/dL, 5.6 mg/dL, and 5.7 mg/dL, respectively. When 114 participants with ABCG2 126QQ and SLC22A12 258WW under medication for hyperuricemia were included in hyperuricemia cases, the sex-age adjusted odds ratio (OR) of hyperuricemia was not significant; OR=1.00 (95% confidence interval, 0.89–1.24) for CT genotype and OR=0.98 (0.84–1.32) for TT genotype, relative to CC genotype. The present study indicated no association between SUA and MTHFR C677T genotype, after the influences of ABCG2 Q126X and SLC22A12 W258X were removed.
Nagoya University School of Medicine
2013-02
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.75.1-2.93
http://hdl.handle.net/2237/17605
https://nagoya.repo.nii.ac.jp/records/15586
10.18999/nagjms.75.1-2.93
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7512/7512.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
75
1-2
93
100
https://nagoya.repo.nii.ac.jp/record/15586/files/10_Hinohara.pdf
application/pdf
130.9 kB
2018-02-20