2024-03-28T09:40:28Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00016535
2023-11-16T05:40:24Z
499:508:509:1510
A Study on the Effect of Hyperbaric Oxygenation on Yoshida Sarcoma : Especially on Its Influence on the Generation Time
OSADA, TAKUJI
open access
In order to observe the effect of hyperbaric oxygenation (ORP) on malignant tumors, the generation time of the Yoshida sarcoma cells was measured under various in vivo conditions. The sarcoma cells transplanted in Donryu rats were divided into 9 groups, which were accordingly exposed to OHPx1, OHPx3, NMO (1 mg/kg)x1, NMO+OHPx1, NMO+OHPx3, MMC (0.5 mg/kg)x1, MMC+OHP x1, and MMC+OHPx3, leaving a group as the control. They were served for the observation of frequency of labeled metaphases, the grain count, and mitotic index of the cells using autoradiography. In the groups of 1 and 3 times of ORP treatment, there were observed the suppression of mitosis, and the prolongation of generation time especially of S phase, due to impaired DNA synthesis. The combination of NMO and OHP rendered more intense suppression of mitosis and more marked prolongation of the generation time than did the NMO treatment alone. By combined treatment of MMC and OHP, the suppression of mitosis and the impairment of DNA synthesis were more marked than by MMC treatment alone. These results suggested the effectiveness of 0HP as an adjuvant to chemotherapy.
Nagoya University School of Medicine
1968-09
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.31.2.243
http://hdl.handle.net/2237/18554
https://nagoya.repo.nii.ac.jp/records/16535
10.18999/nagjms.31.2.243
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/312/312.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
31
2
243
276
https://nagoya.repo.nii.ac.jp/record/16535/files/v31n2p243_276.pdf
application/pdf
4.1 MB
2018-02-20