2024-03-28T21:48:45Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00016696
2023-11-16T05:31:15Z
499:508:509:1526
Study on the Sensitivity Test of Carcinostatic Agents by Acid Phosphatase Activity
IMAIZUMI, MUNEHISA
open access
A new method of tumor sensitivity test by measurement of the activity of acid phosphatase was presented. Treatment of experimental tumor cells with mitomycin C, chromomycin A3 and 5-fiuorouracil showed that deviation index of the specific activity ran well parallel with viability of the cells in vitro. The deviation index of tumor cells was also in agreement with survival times of tumor bearing mice treated with these drugs. Side effects appeared in animals having high values of deviation indices of liver cells. The effectiveness of the drugs was expressed by the values obtained from tumor cells minus those obtained from liver cells. In case of cyclophosphamide, however, it was difficult to judge by this method. In the therapy with mitomycin C, the response was well correlated with the deviation index of tumor cells and the side effect was also correlated with the deviation index of liver cells. This method could predict the effectiveness of carcinostatic agent especially short acting cytocidal drugs.
Nagoya University School of Medicine
1972-03
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.34.4.315
http://hdl.handle.net/2237/18708
https://nagoya.repo.nii.ac.jp/records/16696
10.18999/nagjms.34.4.315
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/344/344.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
34
4
315
333
https://nagoya.repo.nii.ac.jp/record/16696/files/v34n4p315_333.pdf
application/pdf
2.3 MB
2018-02-20