2024-03-29T15:20:48Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00017406
2023-11-16T05:19:39Z
499:508:509:1563
Polymorphisms of Nrf2, an Antioxidative Gene, are Associated with Blood Pressure in Japanese
SHIMOYAMA, YASUHIKO
MITSUDA, YOKO
HAMAJIMA, NOBUYUKI
NIWA, TOSHIMITSU
open access
Nrf2
blood pressure
SNP
cholinesterase
HDL cholesterol
Nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a transcription factor that regulates the expression of antioxidant genes by activating Nrf2-antioxidant response element (ARE) pathway. This study aimed to investigate association of Nrf2 gene single nucleotide polymorphisms (SNPs), rs35652124 (A→G) and rs6721961 (C→A), with various laboratory data in 464 health evaluation examinees. The genotyping of these SNPs was performed using polymerase chain reaction with confronting two-pair primers (PCR-CTPP) assay. The genotype frequencies of rs35652124 SNP were 21.1% for AA, 44.0% for AG, and 34.9% for GG. The frequency of A allele was 0.431. In male subjects, cholinesterase was significantly high, and HDL cholesterol was significantly low in (AG+GG) carriers. In female subjects, diastolic blood pressure (BP) was significantly low in (AG+GG) carriers. The genotype frequencies of rs6721961 SNP were 55.2% for CC, 34.7% for CA, and 10.1% for AA. The frequency of A allele was 0.275. In male subjects, systolic BP, diastolic BP and cholinesterase were significantly low, and iron was significantly high in (CA+AA) carriers. In female subjects, cholinesterase was significantly high in (CA+AA) carriers, and diastolic BP was significantly high in AA carriers. In conclusion, Nrf2 polymorphisms are associated with BP in Japanese.
Nagoya University School of Medicine
2014-02
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.76.1-2.113
http://hdl.handle.net/2237/19489
https://nagoya.repo.nii.ac.jp/records/17406
10.18999/nagjms.76.1-2.113
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7612/7612.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
76
1-2
113
120
https://nagoya.repo.nii.ac.jp/record/17406/files/12_Shimoyama.pdf
application/pdf
184.1 kB
2018-02-21