2024-03-28T23:51:51Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00019174
2023-11-16T05:22:05Z
499:508:509:1674
Impact of the Intraoperative Use of Fibrinogen Concentrate for Hypofibrinogenemia during Thoracic Aortic Surgery
ARAKI, YOSHIMORI
USUI, AKIHIKO
OSHIMA, HIDEKI
ABE, TOMONOBU
FUJIMOTO, KAZURO
MUTSUGA, MASATO
TOKUDA, YOSHIYUKI
TERAZAWA, SACHIE
YAGAMI, KEI
ITO, HIDEKI
open access
fibrinogen concentrate
coagulopathy
thoracic aortic surgery
Thoracic aortic surgery often causes massive bleeding due to coagulopathy. Hypofibrinogenemia is one of the major causative factors, but the utility of the intraoperative administration of fibrinogen concentrate has not yet been proven. The aim of this study was to estimate incidence of hypofibrinogenemia and to evaluate efficacy of using fibrinogen concentrate intraoperatively. The perioperative serum fibrinogen levels (SFL) had routinely been measured in consecutive 216 thoracic aortic surgeries performed from 2010 to 2012. Fibrinogen concentrate was principally used for hypofibrinogenemia (< 150 mg/dl of SFL) at cardiopulmonary bypass (CPB) termination. The patients who received fibrinogen concentrate (FIB group) were compared with the patients who did not received (non Fib group). There were 147 patients (68%) in FIB group at a dose of 5.5±3.5 g. The SFL were dramatically decreased with values of 164±71 mg/dl at CPB termination, compared to the preoperative SFL of 352±131 mg/dl. In the FIB group, the intraoperative and postoperative SFLs were 139±53 and 262±75 (mg/dl), respectively. Thus the SFL was recovered quickly by the administration. 110 cases (51%) showed hypofibrinogenemia at the termination of CPB. The predictors of hypofibrinogenemia were preoperative SFL < 250 mg/dl, emergency surgery and thracoabdominal aortic surgery. Hypofibrinogenemia frequently was observed at the termination of CPB during thoracic aortic surgery. Administering intraoperative fibrinogen concentrate appears to be a useful option to treat coagulopathy.
Nagoya University School of Medicine
2015-02
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.77.1-2.265
http://hdl.handle.net/2237/21280
https://nagoya.repo.nii.ac.jp/records/19174
10.18999/nagjms.77.1-2.265
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7712.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
77
1-2
265
273
https://nagoya.repo.nii.ac.jp/record/19174/files/34_Araki.pdf
application/pdf
197.8 kB
2018-02-21