2024-03-29T10:17:08Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00022437
2023-01-16T04:11:56Z
320:321:322
Liquid-like behavior of chromatin
Maeshima, Kazuhiro
Ide, Satoru
Hibino, Kayo
Sasai, Masaki
open access
(c) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Eukaryotic chromatin is a negatively charged long polymer composed of genomic DNA, histones, and various proteins. The charged property causes the chromatin structure to be dynamically changed. These dynamic changes are critical for genome functions such as gene expression because they directly govern the degree of DNA accessibility. Although the chromatin structure is not yet fully understood, currently increasing evidence suggests that chromatin has a dynamic liquid-like structure based on the 10-nm fiber but not the 30-nm fiber. This liquid-like property can drive the process of ‘scanning and targeting genomic DNA,’ which contributes to various genome functions including gene expression and DNA replication, repair, and recombination. Here, we discuss the liquid-like behavior of chromatin and its physical and biological relevance.
This review comes from a themed issue on Genome architecture and expression, edited by Fred Berger and Pamela Geyer
Elsevier
2016-01
eng
journal article
VoR
http://hdl.handle.net/2237/24585
https://nagoya.repo.nii.ac.jp/records/22437
https://doi.org/10.1016/j.gde.2015.11.006
0959-437X
Current Opinion in Genetics & Development
37
36
45
https://nagoya.repo.nii.ac.jp/record/22437/files/CurrOpnGenDev2016Maeshima.pdf
application/pdf
5.5 MB
2018-02-22