2024-03-28T10:50:28Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00022720
2023-11-16T04:45:33Z
499:508:509:1901
On Hemostatic Studies in Hemophilia
KATSUMI, OTOHEI
open access
In order to elucidate the factors which account for hemorrhagic diathesis of hemophilia, hemostatic studies were carried out in 55 hemophiliacs, consisting of 39 of hemophilia A and 16 of hemophilia B. These patients were classified into severe group (18 cases), moderate group (25 cases) and minimum group (12 cases), according to clinical severity without regard to the data of coagulation test. The results were summarized as follows; 1) The clinical severity in hemophilia did not necessarily coincide with data of coagulation test. Moreover, when hemostatic tests were conducted for pro- longed period on severe cases fluctuations were seen in their hemorrhagic manifestations, but, during same observational period, there showed no variations in the grade of the amount of their congenitally deficient clotting factor. 2) On the other hand, changes in fibrinolytic activity of these hemophiliacs had a definite relationship not only with the grade of clinical severity but also the fluctuations of hemorrhagic manifestation.Based on the above results, it became clear that the hemorrhagic disorders seen in hemophilia can be influenced by fluctuation in the fibrinolytic system.
Nagoya University School of Medicine
1966-06
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.28.3-4.196
http://hdl.handle.net/2237/24873
https://nagoya.repo.nii.ac.jp/records/22720
10.18999/nagjms.28.3-4.196
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/2834/2834.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
28
3-4
196
203
https://nagoya.repo.nii.ac.jp/record/22720/files/v28n34p196_203.pdf
application/pdf
921.7 kB
2018-02-22