2024-03-28T18:41:12Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00022735
2023-11-16T04:45:58Z
499:508:509:1888
Effects of Insulin, Histamine and Vasopressin on Pituitary-adrenocortical Secretion with or without Dexamethasone Pretreatment
ASANO, HARUYOSHI
open access
Adrenal venous 17-hydroxycorticosteroid (17-OHCS) output in response to insulin, histamine and synthetic lysine vasopressin (L-8-V) intravenous administration was determined in nembutal-anesthetized and adrenal-vein cannulated dogs. Dexamethasone pretreatment prevented the adrenal cortical activation provoked by insulin. But when the doses of insulin were increased adrenal cortical response appeared, whereas the larger doses of dexamethasone pretreatment suppressed the adrenal cortical response caused by the increased doses of insulin administration. The quantitative correlationship between the intensity of stress which was represented by the amount of insulin administered and the amount of corticosteroids needed for blocking the stress-induced adrenal cortical activation was observed. Such correlation was also observed between histamine-induced adrenal cortical activation and dexamethasone pretreatment. In hypophysectomized dogs, neither insulin nor histamine could cause adrenal cortical response. On the other hand, dexamethasone pretraetment did not prevent the adrenal cortical activation caused by L-8-V administration, but only the shortening of responding time was observed. L-8-V infused in hypophysectomized dogs did not cause appreciable adrenal cortical activation except for some minimal rise in 17-OHCS output. The enormous doses of dexamethasone did seemingly suppress the adrenal cortical activation caused by less doses of L-8-V. This suggests that massive doses of glucocorticoids might affect pituitary itself.
Nagoya University School of Medicine
1966-12
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.29.2.139
http://hdl.handle.net/2237/24891
https://nagoya.repo.nii.ac.jp/records/22735
10.18999/nagjms.29.2.139
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/292/292.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
29
2
139
154
https://nagoya.repo.nii.ac.jp/record/22735/files/v29n2p139_154.pdf
application/pdf
2.2 MB
2018-02-22