2024-03-29T11:28:53Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00023391
2023-01-16T04:30:20Z
1213:1362:1363
Intramuscular adipose tissue determined by T1-weighted MRI at 3T primarily reflects extramyocellular lipids
Akima, Hiroshi
Hioki, Maya
Yoshiko, Akito
Koike, Teruhiko
Sakakibara, Hisataka
Takahashi, Hideyuki
Oshida, Yoshiharu
open access
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Intramuscular adipose tissue
Spin-echo sequence
Extramyocellular lipids
Ultrasonography
Image analysis
Purpose: The purpose of this study was to assess relationships between intramuscular adipose tissue (IntraMAT) content determined by MRI and intramyocellular lipids (IMCL) and extramyocellular lipids (EMCL) determined by 1H magnetic resonance spectroscopy (1H MRS) or echo intensity determined by B-mode ultrasonography of human skeletal muscles. Methods: Thirty young and elderly men and women were included. T1-weighted MRI was taken from the right mid-thigh to measure IntraMAT content of the vastus lateralis (VL) and biceps femoris (BF) using a histogram shape-based thresholding technique. IMCL and EMCL were measured from the VL and BF at the right mid-thigh using 1H MRS. Ultrasonographic images were taken from the VL and BF of the right mid-thigh to measure echo intensity based on gray-scale level for quantitative analysis. Results: There was a significant correlation between IntraMAT content by MRI and EMCL of the VL and BF (VL, r = 0.506, P < 0.01; BF, r = 0.591, P < 0.001) and between echo intensity and EMCL of the VL and BF (VL, r = 0.485, P < 0.05; BF, r = 0.648, P < 0.01). IntraMAT content was also significantly correlated with echo intensity of the VL and BF (VL, r = 0.404, P < 0.05; BF, r = 0.493, P < 0.01). Conclusion: Our study suggests that IntraMAT content determined by T1-weighted MRI at 3 T primarily reflects extramyocellular lipids, not intramyocellular lipids, in human skeletal muscles.
Elsevier
2016-05
eng
journal article
AM
http://hdl.handle.net/2237/25585
https://nagoya.repo.nii.ac.jp/records/23391
https://doi.org/10.1016/j.mri.2015.12.038
0730-725X
Magnetic Resonance Imaging
34
4
397
403
https://nagoya.repo.nii.ac.jp/record/23391/files/Magnetic_Resonance_Imaging.pdf
application/pdf
573.8 kB
2017-05-01