2024-03-29T15:07:30Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00024655
2023-01-16T04:15:07Z
499:500:501
Responsiveness to bronchodilator procaterol in COPD as assessed by forced oscillation technique
Ito, Satoru
Uchida, Akemi
Isobe, Yoshitaka
Hasegawa, Yoshinori
open access
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Airway
Airway smooth muscle
Forced oscillation technique
Impedance
Bronchodilator
Procaterol
The aim of this retrospective study was to assess responses to a bronchodilator by forced oscillation technique (FOT) and to relate the results of respiratory impedance (Zrs) to spirometric parameters in patients with chronic obstructive pulmonary disease (COPD). Zrs was measured as a function of frequency from 4 to 36 Hz before and after inhalation of procaterol, a short-acting β2-agonist (n = 60). Respiratory resistance (Rrs) and reactance (Xrs) were significantly frequency-dependent, and inspiratory and expiratory phases were different both before and after procaterol inhalation. The Rrs at 4 Hz and Xrs at 4–20 Hz during a whole breath were significantly improved after procaterol inhalation. The response to procaterol inhalation varied among patients, and changes in Xrs at 4 Hz significantly correlated with% change in forced expiratory volume in one second and changes in forced vital capacity. Taken together, Zrs, and specifically Xrs parameters, are sensitive to acute physiological responses to a bronchodilator in COPD.
Elsevier
2017-06
eng
journal article
AM
http://hdl.handle.net/2237/26874
https://nagoya.repo.nii.ac.jp/records/24655
https://doi.org/10.1016/j.resp.2017.02.012
1569-9048
Respiratory Physiology & Neurobiology
240
41
47
https://nagoya.repo.nii.ac.jp/record/24655/files/RESPNB_2017_Ito_for_NU_Library_08-02-2017.pdf
application/pdf
894.6 kB
2018-06-01