2024-03-28T21:20:08Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00024689
2023-11-16T04:17:08Z
499:508:509:2036
Optimized treatment strategy of radiotherapy for early glottic squamous cell carcinomas : An initial analysis
Kimura, Kana
Itoh, Yoshiyuki
Okada, Tohru
Kubota, Seiji
Kawamura, Mariko
Nakahara, Rie
Oie, Yumi
Kozai, Yuka
Takase, Yuuki
Tsuzuki, Hidenori
Nishio, Naoki
Hiramatsu, Mariko
Fujimoto, Yasushi
Mizutani, Takefumi
Naganawa, Shinji
open access
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
early glottic cancer
radiotherapy
chemoradiotherapy
The purpose of this study was to evaluate the clinical outcomes of radiotherapy for patients with T1/T2 glottic carcinoma. Patients with T1/T2 glottic carcinoma histopathologically diagnosed with squamous cell carcinoma and treated at our hospital between 2007 and 2015 were analyzed retrospectively. Our strategy for T1/T2 glottic carcinoma was as follows: radiotherapy alone with 2.25 Gy per fraction to a total of 25–28 fractions for patients with non-bulky T1 glottic carcinoma; concurrent chemoradiotherapy with oral S-1 and radiotherapy with 2 Gy per fraction to a total of 30 fractions for patients with T1 bulky/T2 favorable glottic carcinoma; or chemoradiotherapy with high-dose cisplatin and radiotherapy with 2 Gy per fraction to a total of 35 fractions for T2 unfavorable glottic carcinoma. Forty-eight patients were eligible. The median follow-up period among surviving patients was 38 months (range, 11–107). The disease was T1a in 23%, T1b in 13%, and T2 in 65% of patients. The 3-year local control rate in all patients, T1a, T1b, and T2 was 96.7%, 100%, 100%, and 96.0%, respectively. Of the 46 patients, one with T2 glottic carcinoma developed recurrent disease at the primary site, and one with T2 glottic carcinoma had lymph node recurrences in the neck. Acute Grade 3 dermatitis occurred in 8 (17%) patients and late Grade 2 hypothyroidism occurred in 2 (4%) patients. This retrospective study shows that our optimized treatment strategy of radiotherapy depending on the stage of early glottic carcinoma is not only effective but also well-tolerated.
Nagoya University Graduate School of Medicine, School of Medicine
2017-08
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.79.3.331
http://hdl.handle.net/2237/26911
https://nagoya.repo.nii.ac.jp/records/24689
10.18999/nagjms.79.3.331
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/793.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
79
3
331
338
https://nagoya.repo.nii.ac.jp/record/24689/files/06_Kimura.pdf
application/pdf
293.5 kB
2018-02-22