2024-03-28T14:17:52Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00027029
2023-11-16T04:20:43Z
499:508:509:2328
Laboratory prognostic score for predicting 30-day mortality in terminally ill cancer patients
Kawai, Natsuko
Yuasa, Norihiro
open access
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
end-of-life care
palliative care
prognostic factors
prognosis
blood data
Conventional prognostic scores for terminally ill cancer patients may have less objectivity because they include subjective or categorical variables that do not consider intensity or severity. The aim of this study was to identify prognostic factors for 30-day mortality from routine blood examination of terminally ill cancer patients. A total of 1308 study patients in a hospice setting were divided into investigation (n=761) and validation (n=547) groups. Twenty laboratory blood parameters were analyzed. Multivariate analysis revealed that ten variables (C-reactive protein ≥5.4 mg/dL, serum albumin <2.8 g/dL, blood urea nitrogen ≥21 mg/dL, white blood cell count ≥8.600 × 103/μL, eosinophil percentage <0.8%, neutrophil-to-lymphocyte ratio ≥11.1, hemoglobin level ≥ 13.2 g/dL, mean corpuscular volume ≥ 93.7 fl, red cell distribution width ≥ 16, and platelet count < 159 × 103/μL) were significant independent prognostic factors for 30-day survival. The laboratory prognostic score (LPS) was calculated by the sum of blood indices among the ten variables. The LPS showed acceptable accuracy for 30-day mortality in the investigation and validation groups. LPS 5 (including any five factors) predicted death within 30 days, with a sensitivity of 85%, a specificity of 55%, a positive predictive value of 72%, and a negative predictive value of 74%. The predictive value of LPS was comparable to those of conventional prognostic scores, which include signs and symptoms. The LPS can provide additional information to conventional prognostic scores.
Nagoya University Graduate School of Medicine, School of Medicine
2018-11
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.80.4.571
http://hdl.handle.net/2237/00029229
https://nagoya.repo.nii.ac.jp/records/27029
10.18999/nagjms.80.4.571
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/804.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
80
4
571
582
https://nagoya.repo.nii.ac.jp/record/27029/files/13_Kawai.pdf
application/pdf
555.1 kB