2024-03-29T09:51:49Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00027179
2023-01-16T04:50:37Z
1917:1918:1919
Photocatalytic N-Methylation of Amines over Pd/TiO2 for the Functionalization of Heterocycles and Pharmaceutical Intermediates
Wang, Lyu-Ming
Jenkinson, Kellie
Wheatley, Andrew E. H.
Kuwata, Keiko
Saito, Susumu
Naka, Hiroshi
open access
“This document is the Accepted Manuscript version of a Published Work that appeared in final form in [ACS Sustainable Chemistry & Engineering], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [https://pubs.acs.org/articlesonrequest/AOR-G2mCKTXg7y5BCEnWAmU9].”
Green chemistry
Methanol
Methylation
Pharmaceuticals
Photocatalysis
Amines in heteroaromatic systems and pharmaceutical intermediates were functionalized through N-methylation with methanol using a palladium-loaded titanium dioxide (Pd/TiO2) photocatalyst. This method provides access to a series of tertiary N-methylamines bearing N-, O-, and/or S-containing heteroaromatic functionalities from primary/secondary amines and methanol under mild reaction conditions. Facile syntheses of several pharmaceuticals containing N-methyl or ethyl groups, as well as related deuterated drugs, was achieved through the late-stage functionalization of amines.
ファイル公開:2019-11-05
ACS Publications
2018-11-05
eng
journal article
AM
http://hdl.handle.net/2237/00029385
https://nagoya.repo.nii.ac.jp/records/27179
https://doi.org/10.1021/acssuschemeng.8b03855
2168-0485
ACS Sustainable Chemistry & Engineering
6
11
15419
15424
https://nagoya.repo.nii.ac.jp/record/27179/files/Pd_8926.pdf
application/pdf
714.9 kB
2019-11-05