2024-03-28T20:51:11Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00028234
2023-01-16T04:20:40Z
499:500:501
Treatment of male stress urinary incontinence using autologous adipose-derived regenerative cells: Long-term efficacy and safety
Gotoh, Momokazu
Yamamoto, Tokunori
Shimizu, Shinobu
Matsukawa, Yoshihisa
Kato, Masashi
Majima, Tsuyoshi
Takai, Shun
Funahashi, Yasuhito
Toriyama, Kazuhiro
open access
This is the peer reviewed version of the following article: [Gotoh, M. , Yamamoto, T. , Shimizu, S. , Matsukawa, Y. , Kato, M. , Majima, T. , Takai, S. , Funahashi, Y. and Toriyama, K. (2019), Treatment of male stress urinary incontinence using autologous adipose‐derived regenerative cells: Long‐term efficacy and safety. Int. J. Urol., 26: 400-405. doi:10.1111/iju.13886], which has been published in final form at [https://doi.org/10.1111/iju.13886]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
adipose‐derived regenerative cells
cell therapy
male
prostatectomy
stress urinary incontinence
Objectives: To investigate the long‐term efficacy and safety of periurethral injection of autologous adipose‐derived regenerative cells for the treatment of post‐prostatectomy stress urinary incontinence. Methods: A total of 13 patients with persistent stress urinary incontinence after prostate surgery (radical prostatectomy, 10 patients; holmium laser enucleation of the prostate, three patients) underwent periurethral injection of adipose‐derived regenerative cells and were followed up for >4 years. A 24‐h pad test was carried out for four consecutive days in each evaluation period, and changes in the mean daily leakage volume during the 4 days from baseline to 60 months after treatment were evaluated. Results: The mean follow‐up period was 69 months (range 55–72 months). The mean leakage volume/24 h in all patients changed from 260.7 g to 152.7 g. Urinary incontinence progressively improved up to 12 months after treatment in 10 patients, who maintained improvement up to the final assessment, with the mean daily leakage volume decreasing from 281.5 g to 119.0 g (reduction rate 57.7%). The other three patients showed no improvement at 1 year and at the final assessment. After the perioperative period, significant adverse events or prostate‐specific antigen increase were not observed during long‐term follow up. Conclusions: The present findings suggest that periurethral injection of autologous adipose‐derived regenerative cells is a safe and feasible treatment modality with long‐term efficacy for patients with male stress urinary incontinence caused by urethral sphincter deficiency.
ファイル公開:2020-03-03
Wiley
2019-03-03
eng
journal article
AM
http://hdl.handle.net/2237/00030430
https://nagoya.repo.nii.ac.jp/records/28234
https://doi.org/10.1111/iju.13886
0919-8172
International Journal of Urology
26
3
400
405
https://nagoya.repo.nii.ac.jp/record/28234/files/ADRCs.pdf
application/pdf
308.5 kB
2020-03-03