2024-03-29T09:54:46Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00028401
2023-01-16T04:21:09Z
499:500:501
Divergence and heterogeneity of neoplastic PD‐L1 expression: Two autopsy case reports of intravascular large B‐cell lymphoma
Sakakibara, Ayako
Inagaki, Yuichiro
Imaoka, Eiki
Sakai, Yu
Ito, Masafumi
Ishikawa, Eri
Shimada, Satoko
Shimada, Kazuyuki
Suzuki, Yuka
Nakamura, Shigeo
Satou, Akira
Kohno, Kei
open access
This is the peer reviewed version of the following article: [Sakakibara, A. , Inagaki, Y. , Imaoka, E. , Sakai, Y. , Ito, M. , Ishikawa, E. , Shimada, S. , Shimada, K. , Suzuki, Y. , Nakamura, S. , Satou, A. and Kohno, K. (2019), Divergence and heterogeneity of neoplastic PD‐L1 expression: Two autopsy case reports of intravascular large B‐cell lymphoma. Pathol Int, 69: 148-154. doi:10.1111/pin.12757], which has been published in final form at [https://doi.org/10.1111/pin.12757]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
autopsy
intravascular large B‐cell lymphoma
neoplastic PD‐L1 expression divergence or heterogeneity
Intravascular large B‐cell lymphoma (IVLBCL) is a distinct disease, but the neoplastic PD‐L1 expression on tumor cells may vary among cases. We evaluated 10 IVLBCL autopsy cases for neoplastic PD‐L1 expression, and had positive results in two cases. In one case, neoplastic PD‐L1 expression (SP142, 28‐8, and E1J2J clones) was dependent on the organ and anatomical site (capillaries vs. vessels) of the tumor tissue. Neoplastic PD‐L1 expression was found in tumor cells located in capillaries in the central nervous system, pituitary gland, kidneys, lung, and gastrointestinal tract; sinuses/sinusoids of the spleen, liver, bone marrow, and lymph nodes; and an extravascular location. However, this expression was not detected in tumor cells located in the adrenal gland, thyroid gland, pancreas, ovaries, uterus, pleura, and small or larger‐sized vessels of the lung. The other case showed constant neoplastic PD‐L1 expression on the tumor cells, and in addition to the affected organs, capillaries, and vessels with two anti‐PD‐L1 antibodies (28‐8 and E1J2J, but not SP142). The divergence and heterogeneity of neoplastic PD‐L1 expression were clearly demonstrated in our cases. To the best of our knowledge, this is the first description of divergent neoplastic PD‐L1 expression among the affected organs and anatomical sites in IVLBCL.
ファイル公開:2020-04-08
Wiley
2019-04-08
eng
journal article
AM
http://hdl.handle.net/2237/00030594
https://nagoya.repo.nii.ac.jp/records/28401
https://doi.org/10.1111/pin.12757
1320-5463
Pathology International
69
3
148
154
https://nagoya.repo.nii.ac.jp/record/28401/files/A_Sakakibara.pdf
application/pdf
155.6 kB
2020-04-08