2024-03-28T12:23:14Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00028462
2023-11-16T02:58:33Z
499:508:509:2431
Otological aspects of Fabry disease in patients with normal hearing
Wang, Fei
Yamamoto, Hiroshi
Yoshida, Tadao
Sugimoto, Satofumi
Teranishi, Masaaki
Tsuboi, Kazuya
Sone, Michihiko
open access
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Fabry disease
normal hearing
pure tone audiometry
otoacoustic emission
We investigated the otological aspects of Fabry disease (FD) in patients with normal hearing. Forty-one patients (21 men, 20 women) with bilaterally normal hearing were recruited, and their otological symptoms and hearing evaluations, which included pure tone audiometry (PTA) and distortion product otoacoustic emission (DPOAE), were investigated. Ten of the 21 male (47.6%) and eight of the 20 female (40.0%) patients had otological symptoms, of which tinnitus was the most frequent. Cardiac dysfunction was more frequently observed in female patients. The average thresholds on PTA were below 25 dB at all frequencies, but DPOAE amplitudes were significantly lower in female patients at some frequencies. Otological symptoms were frequently observed in patients with FD, despite their normal hearing levels on PTA. DPOAE might provide useful information regarding cochlear disturbances related to the disease.
Nagoya University Graduate School of Medicine, School of Medicine
2019-08
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.81.3.469
http://hdl.handle.net/2237/00030653
https://nagoya.repo.nii.ac.jp/records/28462
10.18999/nagjms.81.3.469
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/813.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
81
3
469
475
https://nagoya.repo.nii.ac.jp/record/28462/files/12_Wang.pdf
application/pdf
668.5 kB
2019-09-04