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2023-01-16T04:21:41Z
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Cluster of differentiation 36 gene polymorphism (rs1761667) is associated with dietary MUFA intake and hypertension in a Japanese population
Fujii, Ryosuke
Hishida, Asahi
Suzuki, Koji
Imaeda, Nahomi
Goto, Chiho
Hamajima, Nobuyuki
Wakai, Kenji
Kondo, Takaaki
open access
This article has been published in a revised form in [British Journal of Nutrition] [https://doi.org/10.1017/S0007114519000679]. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © 2019 Cambridge University Press.
CD36
Blood pressure
Fatty acids
Single nucleotide polymorphisms
Cluster of differentiation 36 (CD36) is a membrane receptor expressed on a wide variety of human cells. CD36 polymorphisms are reportedly associated with oral fat perception, dietary intake and metabolic disorders. The present study examined associations of two CD36 polymorphisms (rs1761667 and rs1527483) and dietary fat intake, and metabolic phenotypes in a Japanese population. This cross-sectional study was conducted based on clinical information collected from health check-ups in Japan (n 495). Dietary nutrient intake was estimated from a validated short FFQ and adjusted for total energy intake using the residual method. Mean blood pressure was calculated from systolic blood pressure (SBP) and diastolic blood pressure (DBP). Hypertension was defined as SBP ≥ 130 mmHg and/or DBP ≥ 85 mmHg, or use of antihypertensive drugs. Genotyping was performed using PCR with confronting two-pair primers method. Mean age was 63·4 (SD 9·9) years. Individuals with the AA genotype showed higher total fat and MUFA intake (standardised β = 0·110 and 0·087, P = 0·01 and 0·05, respectively) compared with the GG and GA genotypes. For metabolic phenotypes, the AA genotype of rs1761667 had a lower blood pressure compared with the GG genotype (standardised β = –0·123, P = 0·02). Our results suggested that the AA genotype of rs1761667 in the CD36 gene was associated with higher intake of total fat and MUFA and lower risk of hypertension in a Japanese population.
ファイル公開日: 2020/06/14
Cambridge University Press
2019-06-14
eng
journal article
AM
http://hdl.handle.net/2237/00030896
https://nagoya.repo.nii.ac.jp/records/28708
https://doi.org/10.1017/S0007114519000679
0007-1145
British Journal of Nutrition
121
11
1215
1222
https://nagoya.repo.nii.ac.jp/record/28708/files/cluster_of_differentiation_36_gene_polymorphism_rs1761667.pdf
application/pdf
429.4 kB
2020-06-14