2024-03-28T10:56:18Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00028729
2023-01-16T04:42:45Z
499:500:501
Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region
Miyauchi, Tomoya
Tokura, Tatsuya
Kimura, Hiroyuki
Ito, Mikiko
Umemura, Eri
Sato (Boku), Aiji
Nagashima, Wataru
Tonoike, Takashi
Yamamoto, Yasuko
Saito, Kuniaki
Kurita, Kenichi
Ozaki, Norio
open access
This is the peer reviewed version of the following article: [ Miyauchi, T, Tokura, T, Kimura, H, et al. Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region. Hum Psychopharmacol Clin Exp. 2019; 34:e2698. https://doi.org/10.1002/hup.2698], which has been published in final form at [https://doi.org/10.1002/hup.2698]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
atypical odontalgia
burning mouth syndrome
chemokines
cytokines
neuroinflammation
somatic symptom disorder with predominant pain
Objective: Burning mouth syndrome (BMS) and atypical odontalgia (AO) are examples of somatic symptom disorders with predominant pain around the orofacial region. Neuroinflammation is thought to play a role in the mechanisms, but few studies have been conducted. We aimed to better understand the role of neuroinflammation in the pathophysiology and treatment of BMS/AO. Methods: Plasma levels of 28 neuroinflammation‐related molecules were determined in 44 controls and 48 BMS/AO patients both pretreatment and 12‐week post‐treatment with duloxetine. Results: Baseline plasma levels of interleukin (IL)‐1β (p < .0001), IL‐1 receptor antagonist (p < .001), IL‐6 (p < .0001), macrophage inflammatory protein‐1β (p < .0001), and platelet‐derived growth factor‐bb (.04) were significantly higher in patients than in controls. Plasma levels of granulocyte macrophage colony stimulating factor were significantly higher in patients than in controls (p < .001) and decreased with treatment (.009). Plasma levels of eotaxin, monocyte chemoattractant protein‐1, and vascular endothelial growth factor decreased significantly with treatment (p < .001, .022, and .029, respectively). Conclusions: Inflammatory mechanisms may be involved in the pathophysiology and/or treatment response of somatic symptom disorders with predominant pain around the orofacial region.
ファイル公開:2020-07-01
Wiley
2019-07
eng
journal article
AM
http://hdl.handle.net/2237/00030917
https://nagoya.repo.nii.ac.jp/records/28729
https://doi.org/10.1002/hup.2698
0885-6222
Human Psychopharmacology: Clinical and Experimental
34
4
e2698
https://nagoya.repo.nii.ac.jp/record/28729/files/20190315_draft revised.pdf
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