2024-03-19T13:19:50Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00028856
2023-01-16T05:11:08Z
643:666:667
Interconnection between circadian clocks and thyroid function
Ikegami, Keisuke
Refetoff, Samuel
Van Cauter, Eve
Yoshimura, Takashi
open access
Circadian rhythmicity is an approximately 24-h cell-autonomous period driven by transcription–translation feedback loops of specific genes, which are referred to as ‘circadian clock genes’. In mammals, the central circadian pacemaker, which is located in the hypothalamic suprachiasmatic nucleus, controls peripheral circadian clocks. The circadian system regulates virtually all physiological processes, which are further modulated by changes in the external environment, such as light exposure and the timing of food intake. Chronic circadian disruption caused by shift work, travel across time zones or irregular sleep–wake cycles has long-term consequences for our health and is an important lifestyle factor that contributes to the risk of obesity, type 2 diabetes mellitus and cancer. Although the hypothalamic–pituitary–thyroid axis is under the control of the circadian clock via the suprachiasmatic nucleus pacemaker, daily TSH secretion profiles are disrupted in some patients with hypothyroidism and hyperthyroidism. Disruption of circadian rhythms has been recognized as a perturbation of the endocrine system and of cell cycle progression. Expression profiles of circadian clock genes are abnormal in well-differentiated thyroid cancer but not in the benign nodules or a healthy thyroid. Therefore, the characterization of the thyroid clock machinery might improve the preoperative diagnosis of thyroid cancer.
ファイル公開:2020/04/01
Nature
2019-10
eng
journal article
AM
http://hdl.handle.net/2237/00031043
https://nagoya.repo.nii.ac.jp/records/28856
https://doi.org/10.1038/s41574-019-0237-z
1759-5029
Nature Reviews Endocrinology
15
10
590
600
https://nagoya.repo.nii.ac.jp/record/28856/files/20191223NREND-18-170_Rev_Yoshimura.pdf
application/pdf
887.4 kB
2020-04-01