2024-03-28T13:52:10Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00028857
2023-01-16T04:59:32Z
320:321:322
Elastin-like polypeptides as building motifs toward designing functional nanobiomaterials
Le, Duc H. T.
Sugawara-Narutaki, Ayae
open access
Taking inspiration from naturally-occurring proteins, scientists have created protein polymers consisting of functional amino acid sequences that have evolved in nature. The functions of protein polymers can be custom-designed through the modular assembly of protein domains or minimized functional motifs. Elastin-like polypeptides (ELPs) are one of the exquisite building motifs in designing protein polymers. They exhibit stimuli-responsive self-assembling properties, remarkable elasticity, and favorable biological characteristics such as low platelet adhesion and low immunogenicity. With these characteristics, ELP-based materials have been demonstrated to be promising candidates for nanobiomaterial applications such as tissue engineering, drug delivery, and nanobiodevices. This review describes the recent developments in designing modular protein polymers containing ELPs as the building units.
ファイル公開:2020/06/01
Royal Society of Chemistry
2019-06
eng
journal article
AM
http://hdl.handle.net/2237/00031044
https://nagoya.repo.nii.ac.jp/records/28857
https://doi.org/10.1039/C9ME00002J
2058-9689
Molecular Systems Design & Engineering
4
3
545
565
https://nagoya.repo.nii.ac.jp/record/28857/files/MSDE_MS(R)_0226 for submission.pdf
application/pdf
2.2 MB
2020-06-01