2024-03-29T13:55:32Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00028989
2023-01-16T05:03:30Z
329:330:331
REM sleep–active MCH neurons are involved in forgetting hippocampus-dependent memories
Izawa, Shuntaro
Chowdhury, Srikanta
Miyazaki, Toh
Mukai, Yasutaka
Ono, Daisuke
Inoue, Ryo
Ohmura, Yu
Mizoguchi, Hiroyuki
Kimura, Kazuhiro
Yoshioka, Mitsuhiro
Terao, Akira
Kilduff, Thomas S.
Yamanaka, Akihiro
open access
“This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in [Science] on [v.365, n.6459, 20 Sep 2019], DOI: [10.1126/science.aai9057].”
The neural mechanisms underlying memory regulation during sleep are not yet fully understood. We found that melanin concentrating hormone–producing neurons (MCH neurons) in the hypothalamus actively contribute to forgetting in rapid eye movement (REM) sleep. Hypothalamic MCH neurons densely innervated the dorsal hippocampus. Activation or inhibition of MCH neurons impaired or improved hippocampus-dependent memory, respectively. Activation of MCH nerve terminals in vitro reduced firing of hippocampal pyramidal neurons by increasing inhibitory inputs. Wake- and REM sleep–active MCH neurons were distinct populations that were randomly distributed in the hypothalamus. REM sleep state–dependent inhibition of MCH neurons impaired hippocampus-dependent memory without affecting sleep architecture or quality. REM sleep–active MCH neurons in the hypothalamus are thus involved in active forgetting in the hippocampus.
American Association for the Advancement of Science
2019-09-20
eng
journal article
AM
http://hdl.handle.net/2237/00031184
https://nagoya.repo.nii.ac.jp/records/28989
https://doi.org/10.1126/science.aax9238
0036-8075
Science
365
6459
1308
1313
https://nagoya.repo.nii.ac.jp/record/28989/files/Izawa_combined.pdf
application/pdf
14.4 MB
2020-01-15