2024-03-28T09:13:17Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00029356
2023-11-16T03:00:01Z
499:508:509:2478
Stanniocalcin-1 mRNA expression in soft-tissue tumors
Yamagishi, Tetsuro
Kawashima, Hiroyuki
Ogose, Akira
Ariizumi, Takashi
Oike, Naoki
Sasaki, Taro
Hatano, Hiroshi
Endo, Naoto
open access
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Stanniocalcin-1
soft tissue tumor
expression
Stanniocalcin-1 (STC1) is a glycoprotein that was originally identified as a calcium-regulating hormone in bony fish, and that has been shown to also critically mediate cell growth, proliferation and differentiation, etc. in humans. Increased STC1 expression levels have been previously detected in different human cancer samples, such as those isolated from lung, breast, ovary, colon, pancreas, and liver tumors; thus, the present study evaluated STC1 expression in various soft-tissue tumors. STC1 mRNA isolated from 16 cell lines and 186 clinical soft-tissue tumor specimens were analyzed via quantitative real-time PCR, and the calculated expression levels were normalized to those exhibited by STC1-expressing MDA-MB-231 cells. The results of these analyses did not reveal any specific histological tumor types that displayed significantly increased STC1 expression; however, they did not indicate that STC1 expression was significantly higher in malignant compared to benign soft-tissue tumors. Furthermore, in adipocytic tumors, STC1 expression in dedifferentiated liposarcomas was found to be highest and lowest in lipoma tissues, respectively, suggesting that adipocytic tumors may express increasely high levels of STC1 mRNA as they become histologically more advanced. STC1 expression correlates with the malignancy grade in soft-tissue tumors.
Nagoya University Graduate School of Medicine, School of Medicine
2020-02
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.82.1.85
http://hdl.handle.net/2237/00031543
https://nagoya.repo.nii.ac.jp/records/29356
10.18999/nagjms.82.1.85
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/821.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
82
1
85
92
https://nagoya.repo.nii.ac.jp/record/29356/files/11_Yamagishi.pdf
application/pdf
823.2 kB
2020-02-26