2024-03-28T17:06:02Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00029358
2023-11-16T03:00:05Z
499:508:509:2478
A comparison of the features of fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between IgG4-related disease with bilateral hilar lymphadenopathy and sarcoidosis
Ozawa, Yoko
Yamamoto, Hiroshi
Yasuo, Masanori
Komatsu, Masamichi
Ushiki, Atsuhito
Hamano, Hideaki
Uehara, Takeshi
Kawakami, Satoshi
Fujita, Akira
Fujinaga, Yasunari
Oguchi, Kazuhiro
Kawa, Shigeyuki
Hanaoka, Masayuki
open access
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
bilateral hilar lymphadenopathy (BHL)
Fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET)
Immunoglobulin G4-related disease (IgG4-RD)
Sarcoidosis
maximum standardized uptake value (SUVmax)
We aimed to show the differentiation of the degree and distribution on Fluorine-18 fluorodeoxyglucosepositron emission tomography (FDG-PET) between patients with immunoglobulin G4-related disease (IgG4-RD) and sarcoidosis, though both diseases frequently show bilateral hilar lymphadenopathy (BHL). The clinical records were retrospectively reviewed in 25 patients with IgG4-RD with BHL and 15 patients with sarcoidosis (stage I–II) diagnosed at Shinshu University Hospital. All patients underwent FDG-PET at Aizawa Hospital from January 2004 to December 2015. The FDG accumulation pattern and maximum standardized uptake value (SUVmax) of the hilar lymph nodes were compared between the two groups. The IgG4-RD group (21 men; median age 69 years) showed a significant male predominance and older age compared with the sarcoidosis group (3 men, median age 55.4 years). The IgG4-RD group showed a significantly higher incidence of FDG accumulation in the lachrymal gland, submandibular gland, pancreas, prostate and periurethral and periarterial regions compared with the sarcoidosis group. In contrast, the sarcoidosis group showed a significantly higher incidence of FDG accumulation in the supraclavicular and abdominal lymph nodes, muscle and soft tissues compared with the IgG4-RD group. Furthermore, the SUVmax of the hilar lymph nodes was significantly higher in the sarcoidosis group (median 7.20) than in the IgG4-RD group (median 4.20, p=0.002). In conclusion, significant differences were observed in the FDG accumulation patterns and SUVmax values of the hilar lymph nodes between IgG4-RD with BHL and sarcoidosis, although both diseases develop through the lymphatic routes of the lungs and are frequently associated with BHL.
This study was supported by the Research Program of Intractable Disease, the Ministry of Health, Labor, and Welfare of Japan (No. H29-Nanchi-Ippan-058), and the Japan Society for the Promotion of Science (No. 15K09169).
Nagoya University Graduate School of Medicine, School of Medicine
2020-02
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.82.1.101
http://hdl.handle.net/2237/00031545
https://nagoya.repo.nii.ac.jp/records/29358
10.18999/nagjms.82.1.101
http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/821.html
2186-3326
0027-7622
Nagoya Journal of Medical Science
82
1
101
111
https://nagoya.repo.nii.ac.jp/record/29358/files/13_Ozawa.pdf
application/pdf
57.9 MB
2020-02-26