2024-03-29T05:53:58Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00031341
2023-01-16T04:24:55Z
1903:1904:1905
Sulfur depletion induces autophagy through Ecl1 family genes in fission yeast
Shimasaki, Takafumi
Okamoto, Keisuke
Ohtsuka, Hokuto
Aiba, Hirofumi
open access
This is the peer reviewed version of the following article: [Shimasaki, T, Okamoto, K, Ohtsuka, H, Aiba, H. Sulfur depletion induces autophagy through Ecl1 family genes in fission yeast. Genes Cells. 2020; 25: 825–830. https://doi.org/10.1111/gtc.12815], which has been published in final form at [https://doi.org/10.1111/gtc.12815]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
autophagy
chronological lifespan
Ecl1 family genes
Schizosaccharomyces pombe
sulfur depletion
Autophagy is an intracellular degradation system widely conserved among various species. Autophagy is induced by the depletion of various nutrients, and this degradation mechanism is essential for adaptation to such conditions. In this study, we demonstrated that sulfur depletion induces autophagy in the fission yeast Schizosaccharomyces pombe. Based on the finding that autophagy induced by sulfur depletion was completely abolished in a mutant in which the ecl1, ecl2 and ecl3 genes were deleted (Δecls), we report that these three genes are essential for the induction of autophagy by sulfur depletion. Furthermore, autophagy‐defective mutant cells exhibited poor growth and short lifespan (compared with wild‐type cells) under the sulfur‐depleted condition. These results indicated that the mechanism of autophagy is necessary for the appropriate adaptation to sulfur depletion.
ファイル公開:2021-12-01
Wiley
2020-12
eng
journal article
AM
http://hdl.handle.net/2237/00033521
https://nagoya.repo.nii.ac.jp/records/31341
https://doi.org/10.1111/gtc.12815
1356-9597
Genes to Cells
25
12
825
830
https://nagoya.repo.nii.ac.jp/record/31341/files/GENES_TO_CELLS_25_12_2020_825-830.pdf
application/pdf
1.5 MB
2021-12-01