2024-03-29T11:57:48Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:02001164
2023-11-16T02:04:44Z
499:508:509:1624513305190
Outcomes in symptomatic preterm infants with postnatal cytomegalovirus infection
Takemoto, Koji
Oshiro, Makoto
Sato, Yoshiaki
Yamamoto, Hikaru
Ito, Masatoki
Hayashi, Seiji
Kato, Eiko
Kato, Yuichi
Hayakawa, Masahiro
open access
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
cytomegalovirus infections
premature birth
patient outcome assessment
growth & development
case-control studies
Premature infants are at risk for developing symptomatic postnatal cytomegalovirus (CMV) disease, including sepsis-like syndrome. We performed a retrospective case–control study including infants born before 32 weeks of gestation and diagnosed with symptomatic postnatal CMV infection during the neonatal period. Neurodevelopmental outcome was evaluated using the Kyoto Scale of Psychological Development 2001 at 18 months of corrected age and at 3 years of age. Twenty-four infants were diagnosed with postnatal CMV infection; of them, 14 had sepsis-like symptoms and 10 had laboratory test abnormalities only. Home oxygen therapy was used significantly higher in the CMV-positive group compared with the control group at hospital discharge (52% vs 21%, P=0.032). The incidence of neurodevelopmental impairment was not significantly different between the two groups at 18 months of corrected age (29% vs 17%, P=0.48) and at 3 years of age (43% vs 29%, P=0.34). Postnatal CMV infection did not have a significant influence on neurodevelopmental outcomes of symptomatic preterm infants, although those in the CMV-positive group appeared worse. Larger studies with long-term follow-up are needed for a better understanding of continued neurodevelopmental outcomes in preterm infants with postnatal CMV infection.
Nagoya University Graduate School of Medicine, School of Medicine
2021-05
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/nagjms.83.2.311
http://hdl.handle.net/2237/0002001164
https://nagoya.repo.nii.ac.jp/records/2001164
10.18999/nagjms.83.2.311
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/832.html
0027-7622
2186-3326
Nagoya Journal of Medical Science
83
2
311
319
https://nagoya.repo.nii.ac.jp/record/2001164/files/10_Takemoto.pdf
application/pdf
229 KB
2021-06-28