2024-03-28T12:47:36Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:02001549
2023-04-05T00:51:47Z
499:500:501
Long term efficacy and fate of a right ventricular outflow tract replacement using an elastomeric cardiac patch consisting of caprolactone and D,L-lactide copolymers
Fujimoto, Kazuro L
Yamawaki-Ogata, Aika
Uto, Koichiro
Usui, Akihiko
Narita, Yuji
Ebara, Mitsuhiro
open access
© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
poly-ε-caprolactone
Elasticity
Cardiac patch
Myofibroblast
Vascularization
For decades, researchers have investigated the ideal material for clinical use in the cardiovascular field. Several substitute materials are used clinically, but each has drawbacks. Recently we developed biodegradable and elastic poly(ε-caprolactone-co-D,L-lactide) (P(CL-DLLA)) copolymers by adjusting the CL/DLLA composition, and evaluated the long-term efficacy and outcomes of these copolymers when used for right ventricular outflow tract (RVOT) replacement. This P(CL-DLLA) material was processed into a circular patch and used to replace a surgical defect in the RVOT of adult rats. Control rats were implanted with expanded polytetrafluoroethylene (ePTFE). Histologic evaluation was performed at 8, 24, and 48 weeks post-surgery. All animals survived the surgery with no aneurysm formation or thrombus. In all periods, ePTFE demonstrated fibrous tissue. In contrast, at 8 weeks P(CL-DLLA) showed infiltration of macrophages and fibroblast-like cells into the remaining material. At 24 weeks, P(CL-DLLA) was absorbed completely, and muscle-like tissue was present with positive staining for α-sarcomeric actinin and cardiac troponin T (cTnT). At 48 weeks, the cTnT-positive area had increased. The biodegradable and elastic P(CL-DLLA) induced cardiac regeneration throughout the 48-week study period. Future application of this material as a cardiovascular scaffold seems promising.
Elsevier
2023-03-15
2021-03-15
eng
journal article
AM
http://hdl.handle.net/2237/0002001549
https://nagoya.repo.nii.ac.jp/records/2001549
https://doi.org/10.1016/j.actbio.2021.01.022
17427061
Acta Biomaterialia
123
222
229
https://nagoya.repo.nii.ac.jp/record/2001549/files/fujimoto.pdf
application/pdf
2.5 MB
2023-03-15