2024-03-29T01:12:14Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:02001920
2023-01-16T04:42:37Z
499:500:501
Intranasal levels of lead as an exacerbation factor for allergic rhinitis in humans and mice
Xu, Huadong
Ohgami, Nobutaka
Sakashita, Masafumi
Ogi, Kazuhiro
Hashimoto, Kazunori
Tazaki, Akira
Tong, Keming
Aoki, Masayo
Fujieda, Shigeharu
Kato, Masashi
open access
© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Air pollutant
seasonal allergic rhinitis
exacerbation factor
intranasal exposure
lead
Japanese cedar pollen
Background: Air pollutants are suspected to affect pathological conditions of allergic rhinitis (AR). Objectives: After detecting Pb (375 μg/kg) in Japanese cedar pollen, the effects of intranasal exposure to Pb on symptoms of AR were investigated. Methods: Pollen counts, subjective symptoms, and Pb levels in nasal epithelial lining fluid (ELF) were investigated in 44 patients with Japanese cedar pollinosis and 57 controls from preseason to season. Effects of intranasal exposure to Pb on symptoms were confirmed by using a mouse model of AR. Results: Pb levels in ELF from patients were >40% higher than those in ELF from control subjects during the pollen season but not before the pollen season. Pb level in ELF was positively associated with pollen counts for the latest 4 days before visiting a hospital as well as scores of subjective symptoms. Intranasal exposure to Pb exacerbated symptoms in allergic mice, suggesting Pb as an exacerbation factor. Pb levels in ELF and nasal mucosa in Pb-exposed allergic mice were higher than those in Pb-exposed nonallergic mice, despite intranasally challenging the same amount of Pb. Because the increased Pb level in the nasal mucosa of Pb-exposed allergic mice was decreased after washing the nasal cavity, Pb on the surface of but not inside the nasal mucosa may have been a source of increased Pb level in ELF of allergic mice. Conclusions: Increased nasal Pb level partially derived from pollen could exacerbate subjective symptoms of AR, indicating Pb as a novel hazardous air pollutant for AR.
Elsevier
2022-07-01
2021-07
eng
journal article
AM
http://hdl.handle.net/2237/0002001920
https://nagoya.repo.nii.ac.jp/records/2001920
https://doi.org/10.1016/j.jaci.2021.03.019
0091-6749
Journal of Allergy and Clinical Immunology
148
1
139
147.e10
https://nagoya.repo.nii.ac.jp/record/2001920/files/Xu_et_al_2021_JACI-D-20-02028_R2.pdf
application/pdf
4.8 MB
2022-07-01