2024-03-29T12:05:12Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:02002069
2023-01-16T05:08:13Z
499:500:501
Detection of Colorectal Neoplasms Using Linked Color Imaging: A Prospective, Randomized, Tandem Colonoscopy Trial
Hasegawa, Issei
Yamamura, Takeshi
Suzuki, Hiroto
Maeda, Keiko
Sawada, Tsunaki
Mizutani, Yasuyuki
Ishikawa, Eri
Ishikawa, Takuya
Kakushima, Naomi
Furukawa, Kazuhiro
Ohno, Eizaburo
Kawashima, Hiroki
Nakamura, Masanao
Fujishiro, Mitsuhiro
open access
© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Background and aims: A higher adenoma detection rate (ADR) has been shown to be related to a lower incidence and mortality of colorectal cancer. We analyzed the efficacy of linked color imaging (LCI) by assessing the detection, miss, and visibility of various featured adenomas as compared with white light imaging (WLI). Methods: This was a prospective, randomized, tandem trial. The participants were randomly assigned to 2 groups: first observation by LCI, then second observation by WLI (LCI group); or both observations by WLI (WLI group). Suspected neoplastic lesions were resected after magnifying image-enhanced endoscopy. The primary outcome was to compare the ADR during the first observation. Secondary outcomes included evaluation of adenoma miss rate (AMR) and visibility score. Results: A total of 780 patients were randomized, 700 of whom were included in the final analysis. The ADR was 69.6% and 63.2% in the LCI and WLI groups, respectively, with no significant difference. However, LCI improved the average ADR in low-detectors compared with high-detectors (76.0% vs 55.1%; P < .001). Total AMR was 20.6% in the LCI group, which was significantly lower than that in the WLI group (31.1%) (P < .001). AMR in the LCI group was significantly lower, especially for diminutive adenomas (23.4% vs 35.1%; P < .001) and nonpolypoid lesions (25.6% vs 37.9%; P < .001) compared with the WLI group. Conclusion: Although both methods provided a similar ADR, LCI had a lower AMR than WLI. LCI could benefit endoscopists with lower ADR, an observation that warrants additional study. (UMIN Clinical Trials Registry, Number: UMIN000026359).
Elsevier
2022-08-01
2021-08
eng
journal article
AM
http://hdl.handle.net/2237/0002002069
https://nagoya.repo.nii.ac.jp/records/2002069
https://doi.org/10.1016/j.cgh.2021.04.004
1542-3565
Clinical Gastroenterology and Hepatology
19
8
1708
1716.e4
https://nagoya.repo.nii.ac.jp/record/2002069/files/Main_manuscript_document_LCI.pdf
application/pdf
711 KB
2022-08-01