2024-03-28T13:39:22Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:02002214
2023-01-16T05:08:43Z
499:500:501
Instability of speech in Parkinson disease patients with subthalamic nucleus deep brain stimulation
Tanaka, Yasuhiro
Tsuboi, Takashi
Watanabe, Hirohisa
Torii, Jun
Nakatsubo, Daisuke
Maesawa, Satoshi
Sato, Maki
Hiraga, Keita
Satake, Yuki
Yokoi, Katsunori
Hattori, Makoto
Kawabata, Kazuya
Hara, Kazuhiro
Yamamoto, Masahiko
Sobue, Gen
Katsuno, Masahisa
open access
© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Parkinson's disease
Subthalamic nucleus deep brain stimulation
Dysarthria
Instability of speech
Speech rhythm
Cerebellar ataxia
Introduction: The impact of deep brain stimulation (DBS) on speech rhythm and its mechanism remains unclear. We investigated speech rhythm characteristics of patients with Parkinson's disease (PD) treated with subthalamic nucleus (STN) DBS to understand the underlying pathophysiology better. Methods: We enrolled a total of 105 participants and evaluated speech rhythm performances among patients with PD who had undergone STN-DBS (the PD-DBS group), patients with PD treated only with medication (the PD-Med group), patients with cerebellar ataxia (the CA group), and healthy controls (the HC group). Each participant was asked to repeat the syllable/pa/at a comfortable self-chosen steady pace. A widely-used software (the Motor Speech Profile) program performed an acoustic analysis. Results: Compared to the PD-Med and HC groups, speech rate instability (DDKjit) was significantly higher in the PD-DBS and CA groups (p < 0.01). However, after DBS was turned off, the DDKjit of the PD-DBS group improved to a level comparable to that of the PD-Med and HC groups. In contrast to the significantly higher variability of speech volume (DDKcvi) in the CA group, the PD-DBS group showed similar DDKcvi to the PD-Med and HC groups. Conclusions: STN-DBS affects the speech rate stability of patients with PD. Speech rhythm disorders caused by STN-DBS were phenotypically similar to that in CA in terms of interval variability but different regarding amplitude variability. Further studies are warranted to elucidate the underlying pathophysiology of speech rhythm disorders in PD patients treated with DBS.
Elsevier
2022-12-01
2021-12
eng
journal article
AM
http://hdl.handle.net/2237/0002002214
https://nagoya.repo.nii.ac.jp/records/2002214
https://doi.org/10.1016/j.parkreldis.2021.10.029
1353-8020
Parkinsonism & Related Disorders
93
8
11
https://nagoya.repo.nii.ac.jp/record/2002214/files/Tanaka_et_al_Instability_of_speech_in_Parkinson_disease_patients.pdf
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2022-12-01