2024-03-28T10:05:25Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:02005386
2023-04-11T02:26:21Z
1213:1620:1621:1680676320432
Physical exercise started before maturity prevents aging-related insulin resistance in rats
OHSAWA, Isao
SATO, Juichi
OSHIDA, Yoshiharu
SATO, Yuzo
open access
To evaluate the effects of physical exercise on insulin resistance associated with aging, we investigated insulin-induced glucose disposal in mature trained rats (MT, 4 months of age), mature untrained ones (MU, 4 months of age), and young untrained ones (YU, 2 months of age), using the 2-step sequential euglycemic clamp technique (insulin infusion rates: 6 and 30 mU/kg/min). During 30 mU/kg/min clamp, metabolic clearance rates of glucose (MCR) in MU significantly declined compared with YU (P<0.01). MCR during 6 and 30 mU/kg/min clamp were, respectively, significantly higher in MT than in MU (P<0.01). There were no significant differences in MCR between MT and YU. These results suggest that aging process of rats might decrease insulin action in their peripheral tissues predominantly because of post insulin receptor binding defect, and that physical exercise begun before maturity might prevent or delay insulin resistance associated with aging.
名古屋大学総合保健体育科学センター
The Research Center of Health, Physical Fitness and Sports, Nagoya University
1997-03-31
eng
departmental bulletin paper
VoR
https://doi.org/10.18999/njhpfs.20.1.53
http://hdl.handle.net/2237/0002005386
https://nagoya.repo.nii.ac.jp/records/2005386
10.18999/njhpfs.20.1.53
0289-5412
総合保健体育科学
Nagoya Journal of Health, Physical Fitness & Sports
20
1
53
58
https://nagoya.repo.nii.ac.jp/record/2005386/files/njhpfs_20_1_53.pdf
application/pdf
3.6 MB
2023-04-10