2024-03-29T11:37:34Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:02005415
2023-04-13T05:50:52Z
1213:1620:1621:1681180013935
覚醒時と麻酔下におけるインスリン感受性の比較検討 : euglycemic clamp法を用いて
Comparison of insulin sensitivity between awake and anesthetized states
李, 玲
LI, Ling
押田, 芳治
OSHIDA, Yoshiharu
加古, 真実
KAKO, Mami
島戸, 真司
SHIMATO, Shinji
大崎, 暢子
OHSAKI, Nobuko
佐藤, 祐造
SATO, Yuzo
open access
This study was undertaken to determine the effect of pentobarbital anesthesia (40mg/kg, i.p.) on in vivo insulin sensitivity. We performed the euglycemic clamp pocedure (insulin infusion rate: 6.0mU/kg/min) in 8 awake and 9 anesthetized male Wistar rats. Mean body weights, and fasting blood glucose and plasma insulin concentrations were similar in the two groups. There was also no significant difference in blood glucose or plasma insulin levels during the clamp study between the two groups. Glucose disposal rate averaged over 60 ~ 90 min during the euglycemic clamp was significantly (p < 0.01) higher in awake rats (25.1 ± 2.9mg/kg/min) than in anesthetized rats (14.3 ± 0.7mg/kg/min). Glucose metablic clearance rate was also found as shown in glucose disposal rate. These results suggest that anethesia reduces insulin sensitivity in rats.
名古屋大学総合保健体育科学センター
The Research Center of Health, Physical Fitness and Sports, Nagoya University
1996-03-28
jpn
departmental bulletin paper
VoR
https://doi.org/10.18999/njhpfs.19.1.67
http://hdl.handle.net/2237/0002005415
https://nagoya.repo.nii.ac.jp/records/2005415
10.18999/njhpfs.19.1.67
0289-5412
総合保健体育科学
Nagoya Journal of Health, Physical Fitness & Sports
19
1
67
70
https://nagoya.repo.nii.ac.jp/record/2005415/files/njhpfs_19_1_67.pdf
application/pdf
2 MB
2023-04-13