2024-03-29T11:15:49Z
https://nagoya.repo.nii.ac.jp/oai
oai:nagoya.repo.nii.ac.jp:00001362
2023-01-26T05:57:10Z
329:333:334:335
Search for Complex Disease Genes: Achievements and Failures
AXENOVICH, Tatiana I.
3073
BORODIN, Pavel M.
3074
complex diseases
linkage analysis
QTL mapping
allelic association
statistical genetics
2002-12
In this paper we review current methods of mapping complex disease genes. We outline the rationale of these methods, fields of their application, their strong and weak points. The progress in genetic mapping of human diseases has been mainly concerned with the Mendelian diseases. Achievements in identification and mapping of complex disease genes have been less impressive. A substantial progress has been reached in development of statistical methods of complex disease mapping. However, most of them are still based on the implicit assumption that there is a gene with a significant effect. They are effective in cases when a disease is due to mutations in structural genes or in their genetic neighborhood. Statistical methods are capable of isolating the effect of the major gene from the effects of genetic background and environmental noise, and localizing it. However, these methods fail when several genes of equal effect are involved. What hinders the progress in mapping of complex disease gene is not the drawbacks of the methods themselves, but underdevelopment of the general concept of genetic anatomy of complex traits.
国立情報学研究所で電子化したコンテンツを使用している。
departmental bulletin paper
Research Institute of Environmental Medicine, Nagoya University
2002-12
Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University
1/2
46
1
6
http://hdl.handle.net/2237/2772
02870517
eng